Neuroimage - The Consciousness Library

Rapid effects of tryptamine psychedelics on perceptual distortions and early visual cortical population receptive fields.

Neuroimage August 15, 2024 Marta Lapo Pais, Marta Teixeira, Carla Soares et al. 8 citations

N, N-dimethyltryptamine (DMT) is a psychedelic tryptamine acting on 5-HT2A serotonin receptors, which is associated with intense visual hallucinatory phenomena and perceptual changes such as distortions in visual space. The neural underpinnings of these effects remain unknown. We hypothesised that changes in population receptive field (pRF) properties in the primary visual cortex (V1) might...

DOI: 10.1016/j.neuroimage.2024.120718 Full text Serotonin 5-ht2a receptors Population responses Visual cortex +12

Intracranial neural representation of phenomenal and access consciousness in the human brain.

Neuroimage August 15, 2024 Zepeng Fang, Yuanyuan Dang, Xiaoli Li et al. 1 citation

After more than 30 years of extensive investigation, impressive progress has been made in identifying the neural correlates of consciousness (NCC). However, the functional role of spatiotemporally distinct consciousness-related neural activity in conscious perception is debated. An influential framework proposed that consciousness-related neural activities could be dissociated into two distinct...

DOI: 10.1016/j.neuroimage.2024.120699 Full text Saccade Stereoelectroencephalography seeg Visual awareness

Preventive effect of one-session brief focused attention meditation on state fatigue: Resting state functional magnetic resonance imaging study.

Neuroimage August 15, 2024 Noriki Yamaya, Teruo Hashimoto, Shigeyuki Ikeda et al.

The extended practice of meditation may reduce the influence of state fatigue by changing neurocognitive processing. However, little is known about the preventive effects of one-session brief focused attention meditation (FAM) on state fatigue in healthy participants or its potential neural mechanisms. This study examined the preventive effects of one-session brief FAM on state fatigue and its...

DOI: 10.1016/j.neuroimage.2024.120709 Full text Focused attention meditation Functional connectivity Functional near-infrared spectroscopy Meditation-naïve participant +2

Changes in high-order interaction measures of synergy and redundancy during non-ordinary states of consciousness induced by meditation, hypnosis, and auto-induced cognitive trance.

Neuroimage June 1, 2024 Pradeep Kumar, Rajanikant Panda, Kanishka Sharma et al. 20 citations

High-order interactions are required across brain regions to accomplish specific cognitive functions. These functional interdependencies are reflected by synergistic information that can be obtained by combining the information from all the sources considered and redundant information (i.e., common information provided by all the sources). However, electroencephalogram (EEG) functional...

DOI: 10.1016/j.neuroimage.2024.120623 Full text High-order interaction Hypnosis O-information Rajyoga meditation +3

Shared functional connectome fingerprints following ritualistic ayahuasca intake.

Neuroimage 2024 Pablo Mallaroni, Natasha L. Mason, Lilian Kloft et al. 17 citations

The knowledge that brain functional connectomes are unique and reliable has enabled behaviourally relevant inferences at a subject level. However, whether such "fingerprints" persist under altered states of consciousness is unknown. Ayahuasca is a potent serotonergic psychedelic which produces a widespread dysregulation of functional connectivity. Used communally in religious ceremonies, its...

DOI: 10.1016/j.neuroimage.2023.120480 Full text DMT Entheogens Brain connectivity connectome Neuroimaging FMRI +8

LSD-induced changes in the functional connectivity of distinct thalamic nuclei.

Neuroimage December 1, 2023 Stefano Delli Pizzi, Piero Chiacchiaretta, Carlo Sestieri et al. 27 citations

The role of the thalamus in mediating the effects of lysergic acid diethylamide (LSD) was recently proposed in a model of communication and corroborated by imaging studies. However, a detailed analysis of LSD effects on nuclei-resolved thalamocortical connectivity is still missing. Here, in a group of healthy volunteers, we evaluated whether LSD intake alters the thalamocortical coupling in a...

DOI: 10.1016/j.neuroimage.2023.120414 Full text Psilocybin Striatum Thalamo-cortical connectivity Thalamus +9

Classical and non-classical psychedelic drugs induce common network changes in human cortex.

Neuroimage June 1, 2023 Rui Dai, Tony E. Larkin, Zirui Huang et al. 49 citations

The neurobiology of the psychedelic experience is not fully understood. Identifying common brain network changes induced by both classical (i.e., acting at the 5-HT2 receptor) and non-classical psychedelics would provide mechanistic insight into state-specific characteristics. We analyzed whole-brain functional connectivity based on resting-state fMRI data in humans, acquired before and during...

DOI: 10.1016/j.neuroimage.2023.120097 Full text Ketamine LSD Cortex Functional connectivity +6

Not with a "zap" but with a "beep": Measuring the origins of perinatal experience.

Neuroimage June 1, 2023 Joel Frohlich, Tim Bayne, Julia S Crone et al.

When does the mind begin? Infant psychology is mysterious in part because we cannot remember our first months of life, nor can we directly communicate with infants. Even more speculative is the possibility of mental life prior to birth. The question of when consciousness, or subjective experience, begins in human development thus remains incompletely answered, though boundaries can be set using...

DOI: 10.1016/j.neuroimage.2023.120057 Full text Consciousness Fetus Infant Meg +2

Continuous Theta Burst Stimulation to the left anterior medial prefrontal cortex influences metacognitive efficiency.

Neuroimage May 15, 2023 Justyna Hobot, Zuzanna Skóra, Michał Wierzchoń et al.

The contribution of the prefrontal areas to visual awareness is critical for the Global Neuronal Workspace Theory and higher-order theories of consciousness. The goal of the present study was to test the potential engagement of the anterior medial prefrontal cortex (aMPFC) in visual awareness judgements. We aimed to temporarily influence the neuronal dynamics of the left aMPFC via...

DOI: 10.1016/j.neuroimage.2023.119991 Full text Anterior prefrontal cortex Identification task Metacognition Subjective ratings +2

Corrigendum to 'Psilocybin induces spatially constrained alterations in thalamic functional organizaton and connectivity': Neuroimage 2022 Oct 15;260:119434.

Neuroimage May 4, 2023 Andrew Gaddis, Daniel E. Lidstone, Mary Beth Nebel et al. correction

Corrigendum to 'Psilocybin induces spatially constrained alterations in thalamic functional organizaton and connectivity': Neuroimage 2022 Oct 15;260:119434.

DOI: 10.1016/j.neuroimage.2023.120130 Psilocybin Psychedelics Psychedelic compounds Brain function +14

Reduced emergent character of neural dynamics in patients with a disrupted connectome

Neuroimage February 11, 2023 Andrea I. Luppi, Pedro A. M. Mediano, Fernando E. Rosas et al.

High-level brain functions are widely believed to emerge from the orchestrated activity of multiple neural systems. However, lacking a formal definition and practical quantification of emergence for experimental data, neuroscientists have been unable to empirically test this long-standing conjecture. Here we investigate this fundamental question by leveraging a recently proposed framework known...

DOI: 10.1016/j.neuroimage.2023.119926 Full text Whole-brain modelling Network control theory Hierarchy Emergence +2

Neural correlates of consciousness in an attentional blink paradigm with uncertain target relevance.

Neuroimage December 1, 2022 Torge Dellert, Sophie Krebs, Maximilian Bruchmann et al.

Several event-related potentials (ERPs) have been proposed as neural correlates of consciousness (NCC), most prominently the early visual awareness negativity (VAN) and the late P3b component. Highly influential support for the P3b comes from studies utilizing the attentional blink (AB), where conscious perception of a first visual target (T1) impairs reporting a second target (T2) presented...

DOI: 10.1016/j.neuroimage.2022.119679 Full text Attentional blink Consciousness P3b Relevance +1

Psychedelics and schizophrenia: Distinct alterations to Bayesian inference.

Neuroimage November 1, 2022 Hardik Rajpal, Pedro A. M. Mediano, Fernando E. Rosas et al. 23 citations

Schizophrenia and states induced by certain psychotomimetic drugs may share some physiological and phenomenological properties, but they differ in fundamental ways: one is a crippling chronic mental disease, while the others are temporary, pharmacologically-induced states presently being explored as treatments for mental illnesses. Building towards a deeper understanding of these different...

DOI: 10.1016/j.neuroimage.2022.119624 Full text Information theory Predictive processing Psychedelics hallucinogens Entheogens +5

Early and late electrophysiological correlates of gradual perceptual awareness in- and outside the Attentional Blink window.

Neuroimage November 1, 2022 Marie-Luise Roth-Paysen, Anne Bröcker, Maximilian Bruchmann et al.

There is an ongoing debate on the neural correlates of consciousness (NCC) in the attentional blink (AB). Theoretical accounts propose that NCC during the attentional blink occur late in the processing hierarchy and that this quality is specific to the AB. We investigated this question by recording event-related potentials during an AB experiment with faces as T2. We analyzed ERPs to T2 stimuli...

DOI: 10.1016/j.neuroimage.2022.119652 Full text

Psilocybin modulation of time-varying functional connectivity is associated with plasma psilocin and subjective effects

Neuroimage October 27, 2022 Anders Lykkebo-Valløe, Brice Ozenne, Sophia Armand et al. 44 citations

Our findings suggest that the acute perceptual psychedelic effects induced by psilocybin may stem from drug-level associated decreases in the occurrence and duration of lateral and medial frontoparietal connectivity motifs. We apply and argue for a modified approach to modeling eigenvectors produced by LEiDA that more fully acknowledges their underlying structure. Together these findings...

DOI: 10.1016/j.neuroimage.2022.119716 Psilocybin Modulation music Hallucinogen Functional connectivity

Imagetic and affective measures of memory reverberation diverge at sleep onset in association with theta rhythm

Neuroimage October 17, 2022 Natália Bezerra Mota, Ernesto Soares, Edgar Altszyler et al. 5 citations

The 'day residue' - the presence of waking memories into dreams - is a century-old concept that remains controversial in neuroscience. Even at the psychological level, it remains unclear how waking imagery cedes into dreams. Are visual and affective residues enhanced, modified, or erased at sleep onset? Are they linked, or dissociated? What are the neural correlates of these transformations? To...

DOI: 10.1016/j.neuroimage.2022.119690 Affect linguistics Audiology Electroencephalography Mental image +3

Psilocybin induces spatially constrained alterations in thalamic functional organizaton and connectivity.

Neuroimage October 15, 2022 Andrew Gaddis, Daniel E. Lidstone, Mary Beth Nebel et al. 38 citations

Classic psychedelics, such as psilocybin and LSD, and other serotonin 2A receptor (5-HT2AR) agonists evoke acute alterations in perception and cognition. Altered thalamocortical connectivity has been hypothesized to underlie these effects, which is supported by some functional MRI (fMRI) studies. These studies have treated the thalamus as a unitary structure, despite known differential 5-HT2AR...

DOI: 10.1016/j.neuroimage.2022.119434 Full text Psilocybin Functional connectivity Independent component analysis Resting state +10

Metastability, fractal scaling, and synergistic information processing: What phase relationships reveal about intrinsic brain activity

Neuroimage July 1, 2022 Fran Hancock, Joana Cabral, Andrea I. Luppi et al. 40 citations

Dynamic functional connectivity (dFC) in resting-state fMRI holds promise to deliver candidate biomarkers for clinical applications. However, the reliability and interpretability of dFC metrics remain contested. Despite a myriad of methodologies and resulting measures, few studies have combined metrics derived from different conceptualizations of brain functioning within the same analysis -...

DOI: 10.1016/j.neuroimage.2022.119433 Interpretability Metric unit Artificial intelligence Resting State FMRI +2

Towards a mechanistic understanding of mindfulness-based stress reduction (MBSR) using an RCT neuroimaging approach: Effects on regulating own stress in social and non-social situations.

Neuroimage July 1, 2022 Simon Guendelman, Mareike Bayer, Kristin Prehn et al.

Although much research has shown that mindfulness-based interventions (MBIs) can reduce psychological stress, it is less clear if effects generalize to everyday social situations, which range among the largest stress triggers. Furthermore, mechanisms of MBIs have not been fully established. Emotion regulation (ER) has been suggested as one key mechanism, yet the role of cognitive reappraisal...

DOI: 10.1016/j.neuroimage.2022.119059 Full text Neuroplasticity Acceptance Cognitive reappraisal Empathy +2

Temporal continuity of self: Long autocorrelation windows mediate self-specificity

Neuroimage May 11, 2022 David Smith, Annemarie Wolff, Angelika Wolman et al. 40 citations

The self is characterized by an intrinsic temporal component consisting in continuity across time. On the neural level, this temporal continuity manifests in the brain's intrinsic neural timescales (INT) that can be measured by the autocorrelation window (ACW). Recent EEG studies reveal a relationship between resting state ACW and self-consciousness. However, it remains unclear whether ACW...

DOI: 10.1016/j.neuroimage.2022.119305 Narrative Electroencephalography Self Cognitive psychology +3

Serotonergic psychedelic drugs LSD and psilocybin reduce the hierarchical differentiation of unimodal and transmodal cortex.

Neuroimage April 25, 2022 Manesh Girn, Leor Roseman, Boris C. Bernhardt et al. 112 citations

Lysergic acid diethylamide (LSD) and psilocybin are serotonergic psychedelic compounds with potential in the treatment of mental health disorders. Past neuroimaging investigations have revealed that both compounds can elicit significant changes to whole-brain functional organization and dynamics. A recent proposal linked past findings into a unified model and hypothesized reduced whole-brain...

DOI: 10.1016/j.neuroimage.2022.119220 Full text LSD Psilocybin Psychedelics Powerful compounds +6

Dynamic reconfiguration of frequency-specific cortical coactivation patterns during psychedelic and anesthetized states induced by ketamine

Neuroimage January 7, 2022 Duan Li, Phillip E. Vlisides, George A. Mashour 24 citations

Recent neuroimaging studies have demonstrated that spontaneous brain activity exhibits rich spatiotemporal structure that can be characterized as the exploration of a repertoire of spatially distributed patterns that recur over time. The repertoire of brain states may reflect the capacity for consciousness, since general anesthetics suppress and psychedelic drugs enhance such dynamics. However,...

DOI: 10.1016/j.neuroimage.2022.118891 Ketamine Wakefulness Consciousness Repertoire +1

The EEG spectral properties of meditation and mind wandering differ between experienced meditators and novices

Neuroimage October 1, 2021 Julio Rodriguez-Larios, Eduardo A. Bracho Montes de Oca, Kaat Alaerts

Previous literature suggests that individuals with meditation training become less distracted during meditation practice. In this study, we assess whether putative differences in the subjective experience of meditation between meditators and non-meditators are reflected in EEG spectral modulations. For this purpose, we recorded electroencephalography (EEG) during rest and two breath focus...

DOI: 10.1016/j.neuroimage.2021.118669 Full text

Decreased emotional reactivity after 3-month socio-affective but not attention- or meta-cognitive-based mental training: A randomized, controlled, longitudinal fMRI study.

Neuroimage August 15, 2021 Pauline Favre, Philipp Kanske, Haakon Engen et al.

Meditation-based mental training interventions show physical and mental health benefits. However, it remains unclear how different types of mental practice affect emotion processing at both the neuronal and the behavioural level. In the context of the ReSource project, 332 participants underwent an fMRI scan while performing an emotion anticipation task before and after three 3-month training...

DOI: 10.1016/j.neuroimage.2021.118132 Full text Meditation Mindfulness Compassion Emotion +2

Hypostability in the default mode network and hyperstability in the frontoparietal control network of dynamic functional architecture during rumination

Neuroimage July 29, 2021 Xiao Chen (陈骁), Chao-Gan Yan (严超赣)

The neural underpinnings of rumination can be characterized by its specific dynamic nature. Temporal stability is the stable and consistent representation of information by a distributed neural activity and connectivity pattern across brain regions. Although stability is a key feature of the brain's functional architecture, its profiles supporting rumination remain elusive. We characterized the...

DOI: 10.1016/j.neuroimage.2021.118427 Full text Default mode network Dynamic functional connectivity Frontoparietal control network Fluctuation +2

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