Psilocybin modulation of time-varying functional connectivity is associated with plasma psilocin and subjective effects
Anders Lykkebo-Valløe, Brice Ozenne, Sophia Armand, Morten Mørup, Melanie Ganz, Anders S. Olsen, M. Madsen, Dea Siggaard Stenbæk, Gitte M. Knudsen, Patrick M. Fisher
Neuroimage October 27, 2022 DOI: 10.1016/j.neuroimage.2022.119716 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Preprint Peer reviewed |
|---|---|
| Intervention | Psilocybin |
| Topics | Psilocybin |
| Keywords | Modulation music Hallucinogen Functional connectivity |
| Citations | 44 |
| Key points | Psilocybin-induced acute perceptual psychedelic effects may stem from decreases in the occurrence and duration of lateral and medial frontoparietal connectivity motifs. |
Abstract
Our findings suggest that the acute perceptual psychedelic effects induced by psilocybin may stem from drug-level associated decreases in the occurrence and duration of lateral and medial frontoparietal connectivity motifs. We apply and argue for a modified approach to modeling eigenvectors produced by LEiDA that more fully acknowledges their underlying structure. Together these findings contribute to a more comprehensive neurobiological framework underlying acute effects of serotonergic psychedelics.