bioRxiv (Cold Spring Harbor Laboratory)
April 2, 2026
Maja Wójcik, Paweł Orłowski, Stanisław Adamczyk et al.
Abstract Background Contemporary research indicates that psychedelics induce notable neurophysiological changes, some lasting weeks to months after a single dose. However, most evidence derives from acute administration studies and limited post-acute follow-ups. Long-term naturalistic psychedelic users remain critically underexamined, yet may exhibit distinct neurobiological profiles informing...
Progress in neuro-psychopharmacology & biological psychiatry
January 10, 2025
Anastasia Ruban, Mikołaj Magnuski, Justyna Hobot et al.
1 citation
Psychedelics have gained increasing interest in scientific research due to their ability to induce profound alterations in perception, emotional processing and self-consciousness. However, the research regarding the functioning of individuals who use psychedelics in naturalistic contexts remains limited. Here we aim to explore psychological and neurophysiological differences between...
Psychophysiology
August 1, 2024
Paweł Orłowski, Justyna Hobot, Anastasia Ruban et al.
5 citations
Classic psychedelics are able to profoundly alter the state of consciousness and lead to acute experiences of ego dissolution - the blurring of the distinction between representations of self and the external world. However, whether repeated use of psychedelics is associated with more prolonged and permanent modifications to the concept of self remains to be investigated. Therefore, we...
February 3, 2024
Anastasia Ruban, Mikołaj Magnuski, Justyna Hobot et al.
1 citation
preprint
Psychedelics have gained increasing interest in scientific research due to their ability to induce profound alterations in perception, emotional processing and self-consciousness. However, the research regarding the short- and long-term impact of using psychedelics in non-controlled, naturalistic contexts remains limited. Here we aim to fill this gap and explore differences between naturalistic...
December 28, 2023
Paweł Orłowski, Justyna Hobot, Anastasia Ruban et al.
1 citation
preprint
Classic psychedelics are able to profoundly alter the state of consciousness and lead to acute experiences of ego dissolution – the blurring of the distinction between representations of self and the external world. However, whether repeated use of psychedelics is associated with more prolonged and permanent modifications to the concept of self remains to be investigated. Therefore, we...
October 9, 2023
Paweł Orłowski, Justyna Hobot, Anastasia Ruban et al.
preprint
Previous research indicates that psychedelic substances taken in well-controlled laboratory or therapeutic settings have the potential to decrease negative and increase positive emotional reactivity. However, it is unclear whether similar effects are associated with using psychedelics in less-controlled naturalistic environments. Therefore, in the present study we compared neural markers of...
Neuroimage
May 15, 2023
Justyna Hobot, Zuzanna Skóra, Michał Wierzchoń et al.
The contribution of the prefrontal areas to visual awareness is critical for the Global Neuronal Workspace Theory and higher-order theories of consciousness. The goal of the present study was to test the potential engagement of the anterior medial prefrontal cortex (aMPFC) in visual awareness judgements. We aimed to temporarily influence the neuronal dynamics of the left aMPFC via...
Journal of Psychopharmacology
August 1, 2022
Paweł Orłowski, Anastasia Ruban, Jan Szczypiński et al.
40 citations
Background: Psychedelics are able to acutely alter emotional reactivity and self-consciousness. However, whether the regular naturalistic use of psychedelics can be linked to more persistent trait-level changes in these domains remains an open question. Aim: To test the hypotheses that (1) using psychedelics is related to higher positive and lower negative emotional reactivity; and (2) an...
September 23, 2021
Paweł Orłowski, Anastasia Ruban, Jan Szczypiński et al.
preprint
Background: Psychedelics are able to acutely alter emotional reactivity and self-consciousness. However, whether regular, naturalistic use of psychedelics can be linked to more persistent, trait-level changes in these domains remains an open question.Aim: To test three hypotheses: i) psychedelics use is related to higher positive and lower negative emotional reactivity; ii) psychedelics use is...