Neuroscience and Biobehavioral Reviews - The Consciousness Library

The Impact of Mindfulness Meditation on the Wandering Mind: a Systematic Review.

Neuroscience and Biobehavioral Reviews September 21, 2021 Susanna Feruglio, Alessio Matiz, G. Pagnoni et al.

Through the practice of Mindfulness Meditation (MM), meditators become familiar with the observation of ongoing spontaneous thoughts, while maintaining an attitude of openness and equanimity. The aim of this systematic review is to present a synthesis of available findings of the short and long-term effects of MM on mind wandering (MW). We included studies that considered both first-person and...

DOI: 10.1016/j.neubiorev.2021.09.032 Full text

From many to (n)one: Meditation and the plasticity of the predictive mind.

Neuroscience and Biobehavioral Reviews September 1, 2021 Ruben Laukkonen, Heleen A. Slagter 183 citations

How profoundly can humans change their own minds? In this paper we offer a unifying account of deconstructive meditation under the predictive processing view. We start from simple axioms. First, the brain makes predictions based on past experience, both phylogenetic and ontogenetic. Second, deconstructive meditation brings one closer to the here and now by disengaging anticipatory processes. We...

DOI: 10.1016/j.neubiorev.2021.06.021 Full text Meditation Attention Consciousness Insight +5

Therapeutic potential of ketamine for alcohol use disorder.

Neuroscience and Biobehavioral Reviews July 1, 2021 Stephen D Worrell, Thomas J Gould 47 citations

Excessive alcohol consumption is involved in 1/10 of deaths of U.S. working-age adults and costs the country around $250,000,000 yearly. While Alcohol Use Disorder (AUD) pathology is complex and involves multiple neurotransmitter systems, changes in synaptic plasticity, hippocampal neurogenesis, and neural connectivity have been implicated in the behavioral characteristics of AUD. Depressed...

DOI: 10.1016/j.neubiorev.2021.05.006 Full text Addiction Depression Ketamine PTSD +3

The Effects of Ketamine on Cognition in Treatment-Resistant Depression: A Systematic Review and Priority Avenues for Future Research.

Neuroscience and Biobehavioral Reviews November 23, 2020 Hartej Gill, Barjot Gill, Nelson B Rodrigues et al. 92 citations

Replicated evidence has documented cognitive deficits in populations with treatment-resistant depression (TRD). Approximately 40% of patients with MDD present with impairment of one or more cognitive domains. As such, there is an unmet need to discover treatments that have pro-cognitive effects in TRD patients. Ketamine has demonstrated efficacy as a rapid-onset intervention for the treatment...

DOI: 10.1016/j.neubiorev.2020.11.020

Neural signs and mechanisms of consciousness: Is there a potential convergence of theories of consciousness in sight?

Neuroscience and Biobehavioral Reviews August 9, 2020 Georg Northoff, Victor A. F. Lamme

Various theories for the neural basis of consciousness have been proposed, suggesting a diversity of neural signs and mechanisms. We ask to what extent this diversity is real, or whether many theories share the same basic ideas with a potential for convergence towards a more unified theory of the neural basis of consciousness. For that purpose, we review and compare the various neural signs,...

DOI: 10.1016/j.neubiorev.2020.07.019

Neuroimaging the Consciousness of Self: Review, and Conceptual-Methodological Framework.

Neuroscience and Biobehavioral Reviews January 26, 2020 Paul Frewen, M. Schroeter, Giuseppe Riva et al.

We review neuroimaging research investigating self-referential processing (SRP), that is, how we respond to stimuli that reference ourselves, prefaced by a lexical-thematic analysis of words indicative of "self-feelings". We consider SRP as occurring verbally (V-SRP) and non-verbally (NV-SRP), both in the controlled, "top-down" form of introspective and interoceptive tasks, respectively, as...

DOI: 10.1016/j.neubiorev.2020.01.023 Full text

Towards a comparative science of emotion: Affect and consciousness in humans and animals

Neuroscience and Biobehavioral Reviews November 25, 2019 E. Paul, Shlomi Sher, M. Tamietto et al.

Highlights • Emotions comprise conscious, behavioural, physiological and cognitive elements.• Neural correlates of conscious emotion can be investigated in humans and animals.• Contemporary theories of consciousness have differing implications for animals.

DOI: 10.1016/j.neubiorev.2019.11.014 Full text

Toward a Theory of Consciousness: A Review of The Neural Correlates of Inattentional Blindness.

Neuroscience and Biobehavioral Reviews September 1, 2019 B. Hutchinson

The neuroscientific study of consciousness involves examining candidate markers of consciousness under conditions where awareness varies. One such method for manipulating awareness is inattentional blindness. Whereas other methods of studying consciousness have been reviewed elsewhere, there has been little effort toward cataloguing work which has studied inattentional blindness using...

DOI: 10.1016/j.neubiorev.2019.06.003

Reframing schizophrenia and autism as self-consciousness disorders associating a deficit of theory of mind and empathy with social communication impairments.

Neuroscience and Biobehavioral Reviews August 1, 2019 Sylvie Tordjman, Macarena-Paz Celume, L. Denis et al.

Prior observations and studies suggest self-consciousness disorders in schizophrenia and Autism Spectrum Disorder (ASD), two neurodevelopmental disorders sharing social communication impairments. First, the relationships between schizophrenia and autism are explored regarding social communication impairments. Then, self-consciousness disorders in schizophrenia and autism are described and...

DOI: 10.1016/j.neubiorev.2019.04.007 Full text

Conflicting emergences. Weak vs. strong emergence for the modelling of brain function.

Neuroscience and Biobehavioral Reviews April 1, 2019 Federico Turkheimer, Peter J. Hellyer, Angie A. Kehagia et al.

The concept of "emergence" has become commonplace in the modelling of complex systems, both natural and man-made; a functional property" emerges" from a system when it cannot be readily explained by the properties of the system's sub-units. A bewildering array of adaptive and sophisticated behaviours can be observed from large ensembles of elementary agents such as ant colonies, bird flocks or...

DOI: 10.1016/j.neubiorev.2019.01.023 Full text Bayesian inference Brain Computational models Free energy principle +5

The social transmission of metacontrol policies: Mechanisms underlying the interpersonal transfer of persistence and flexibility.

Neuroscience and Biobehavioral Reviews October 1, 2017 Bernhard Hommel, Lorenza S. Colzato

Humans often face binary cognitive-control dilemmas, with the choice between persistence and flexibility being a crucial one. Tackling these dilemmas requires metacontrol, i.e., the control of the current cognitive-control policy. As predicted from functional, psychometric, neuroscientific, and modeling approaches, interindividual variability in metacontrol biases towards persistence or...

DOI: 10.1016/j.neubiorev.2017.01.009 Full text Meditation Action Cognitive control Culture +6

How do the brain's time and space mediate consciousness and its different dimensions? Temporo-spatial theory of consciousness (TTC).

Neuroscience and Biobehavioral Reviews September 1, 2017 Georg Northoff, Zirui Huang 235 citations

Time and space are the basic building blocks of nature. As a unique existent in nature, our brain exists in time and takes up space. The brain's activity itself also constitutes and spreads in its own (intrinsic) time and space that is crucial for consciousness. Consciousness is a complex phenomenon including different dimensions: level/state, content/form, phenomenal aspects, and cognitive...

DOI: 10.1016/j.neubiorev.2017.07.013 Full text Phenomenology Consciousness Cross-frequency coupling Frequency nestedness +8

Recommendation to reconsider examining cannabis subtypes together due to opposing effects on brain, cognition and behavior

Neuroscience and Biobehavioral Reviews June 1, 2017 Kristine Rømer Thomsen, M. B. Callesen, S. W. F. Ewing

Cannabis use represents a major public health issue throughout the globe. Yet, we still lack the most fundamental knowledge on long-term effects of cannabis on neural, cognitive, and behavioral function. Part of this stems from how cannabis has been measured historically. To this end, most empirical examinations of cannabis have consolidated all types of cannabis collectively. However, this...

DOI: 10.1016/j.neubiorev.2017.05.025 Full text

Hypnosis and top-down regulation of consciousness.

Neuroscience and Biobehavioral Reviews February 4, 2017 Devin B. Terhune, Axel Cleeremans, Amir Raz et al.

Hypnosis is a unique form of top-down regulation in which verbal suggestions are capable of eliciting pronounced changes in a multitude of psychological phenomena. Hypnotic suggestion has been widely used both as a technique for studying basic science questions regarding human consciousness but also as a method for targeting a range of symptoms within a therapeutic context. Here we provide a...

DOI: 10.1016/j.neubiorev.2017.02.002 Full text

Functional neuroanatomy of meditation: A review and meta-analysis of 78 functional neuroimaging investigations.

Neuroscience and Biobehavioral Reviews March 21, 2016 K. Fox, Matthew L. Dixon, Savannah Nijeboer et al.

Meditation is a family of mental practices that encompasses a wide array of techniques employing distinctive mental strategies. We systematically reviewed 78 functional neuroimaging (fMRI and PET) studies of meditation, and used activation likelihood estimation to meta-analyze 257 peak foci from 31 experiments involving 527 participants. We found reliably dissociable patterns of brain...

DOI: 10.1016/j.neubiorev.2016.03.021 Full text

The Prosocial Effects of 3,4-methylenedioxymethamphetamine (MDMA): Controlled Studies in Humans and Laboratory Animals

Neuroscience and Biobehavioral Reviews September 25, 2015 Philip Kamilar-Britt, G. Bedi 165 citations

Users of ±3,4-Methylenedioxymethamphetamine (MDMA; ‘ecstasy’) report prosocial effects such as sociability and empathy. Supporting these apparently unique social effects, data from controlled laboratory studies indicate that MDMA alters social feelings, information processing, and behavior in humans, and social behavior in rodents. Here, we review this growing body of evidence. In rodents, MDMA...

DOI: 10.1016/j.neubiorev.2015.08.016 Full text

Cannabis, psychosis and the thalamus: a theoretical review.

Neuroscience and Biobehavioral Reviews May 1, 2013 Zoran Vukadinovic, Merrill S Herman, Ivana Rosenzweig

The role of cannabis in the etiology of schizophrenia has been documented as possibly the strongest environmental risk factor. However, the pathomechanism whereby cannabis use increases this risk has not yet been identified. We argue that this pathomechanism may involve direct effects of exogenous cannabinoids on T-type calcium channels in the thalamus. These channels are crucial for...

DOI: 10.1016/j.neubiorev.2013.02.013 Full text

Models of schizophrenia in humans and animals based on inhibition of NMDA receptors.

Neuroscience and Biobehavioral Reviews July 1, 2008 Vĕra Bubeníková‐valešová, Jiří Horáček, Monika Vrajová et al.

The research of the glutamatergic system in schizophrenia has advanced with the use of non-competitive antagonists of glutamate NMDA receptors (phencyclidine, ketamine, and dizocilpine), which change both human and animal behaviour and induce schizophrenia-like manifestations. Models based on both acute and chronic administration of these substances in humans and rats show phenomenological...

DOI: 10.1016/j.neubiorev.2008.03.012 Full text

Effects of diazepam, citalopram, methadone and naloxone on PCP-induced stereotyped behaviour and social isolation in the rat social interaction test.

Neuroscience and Biobehavioral Reviews 1998 F Sams-Dodd

Phencyclidine (PCP) can induce a model psychosis in humans that mimics the positive and negative symptoms of schizophrenia. In the social interaction test PCP induces stereotyped behaviour and social isolation in rats, and these behaviours can be inhibited by antipsychotic drugs. In order to further evaluate the predictive validity of this model of schizophrenia the anxiolytic diazepam...

DOI: 10.1016/s0149-7634(98)00030-x Full text

Opposite effects of N,N-dimethyltryptamine (DMT) and 5-methoxy-n,n-dimethyltryptamine (5-MeODMT) on acoustic startle: spinal vs brain sites of action.

Neuroscience and Biobehavioral Reviews 1982 R L Commissaris, M Davis 25 citations

The present studies examined the role of the spinal cord and the brain in mediating the effects of the hallucinogens N,N-dimethyltryptamine (DMT) and 5-methoxy-N,N-dimethyltryptamine (5-MeODMT) on the acoustic startle response in the rat. Systemic administration of these agents, which distributes to both the brain and spinal cord, produced opposite effects, as DMT depressed and 5-MeODMT...

DOI: 10.1016/0149-7634(82)90034-3 Full text

Nerve terminal effects of indoleamine psychotomimetics on 5-hydroxytryptamine.

Neuroscience and Biobehavioral Reviews 1982 A E Halaris 4 citations

The mode of action of indoleamine psychotomimetics has been closely linked to 5-HT. Early work showed increases in rat brain levels of 5-HT which were later localized to the nerve-ending fraction. With improved methodology, the 5-HT increment was further detected in the synaptic vesicle fraction. These effects were obtained with several indoleamine hallucinogens but not with mescaline. LSD has...

DOI: 10.1016/0149-7634(82)90029-x Full text

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