Models of schizophrenia in humans and animals based on inhibition of NMDA receptors.
Neuroscience and Biobehavioral Reviews July 1, 2008 Vĕra Bubeníková‐valešová, Jiří Horáček, Monika Vrajová et al.
The research of the glutamatergic system in schizophrenia has advanced with the use of non-competitive antagonists of glutamate NMDA receptors (phencyclidine, ketamine, and dizocilpine), which change both human and animal behaviour and induce schizophrenia-like manifestations. Models based on both acute and chronic administration of these substances in humans and rats show phenomenological...