bioRxiv : the preprint server for biology
June 12, 2026
Timothy Lawn, Johan Nakuci, Steve Cr Williams et al.
Analyses of neuroimaging data increasingly leverage the distribution of neurotransmitter receptors derived from Positron Emission Tomography (PET) to bridge the gap between micro- and macro-scale brain function. However, these receptor maps are highly spatially overlapping which can give rise to interpretive and analytical challenges. Here, we systematically investigate the impact of spatial...
Frontiers in Psychiatry
2025
Eric C Bettelheim, Jingyi Liu, Paola Dazzan et al.
Substantial evidence demonstrates that the brain is more interested in faces than in other subjects and that self-related material, particularly self-images, have higher saliency than non-self-referential material. Studies of self-portraits have revealed correlations between stylistic elements and artists' states of mind. Edvard Munch, a founder of Expressionism and most famous for "The...
Preprints.org
July 21, 2023
Fran Hancock, Fernando E. Rosas, Mengsen Zhang et al.
16 citations
preprint
Healthy brain functioning depends on balancing stable integration between brain areas for effective coordinated functioning, with bursts of desynchronisation to allow subsystems to reconfigure and express functional specialisation. Metastability, a concept originated in statistical physics and dynamical systems theory, has been proposed as a key signature that characterises this balance....
Frontiers in network physiology
2023
Louis-David Lord, Timoteo Carletti, Henrique M. Fernandes et al.
In recent years, brain imaging studies have begun to shed light on the neural correlates of physiologically-reversible altered states of consciousness such as deep sleep, anesthesia, and psychedelic experiences. The emerging consensus is that normal waking consciousness requires the exploration of a dynamical repertoire enabling both global integration i.e., long-distance interactions between...
Neuroimage
July 1, 2022
Fran Hancock, Joana Cabral, Andrea I. Luppi et al.
40 citations
Dynamic functional connectivity (dFC) in resting-state fMRI holds promise to deliver candidate biomarkers for clinical applications. However, the reliability and interpretability of dFC metrics remain contested. Despite a myriad of methodologies and resulting measures, few studies have combined metrics derived from different conceptualizations of brain functioning within the same analysis -...
Translational Psychiatry
August 15, 2021
Katherine Beck, Atheeshaan Arumuham, Mattia Veronese et al.
Abstract N-methyl-D-aspartate receptor (NMDAR) hypofunction is hypothesised to underlie psychosis but this has not been tested early in illness. To address this, we studied 40 volunteers (21 patients with first-episode psychosis and 19 matched healthy controls) using PET imaging with an NMDAR selective ligand, [18F]GE-179, that binds to the ketamine binding site to index its distribution volume...
Neuroimage
April 4, 2019
Ottavia Dipasquale, Pierluigi Selvaggi, Mattia Veronese et al.
79 citations
One of the main limitations of pharmacological fMRI is its inability to provide a molecular insight into the main effect of compounds, leaving an open question about the relationship between drug effects and haemodynamic response. The aim of this study is to investigate the acute effects of 3,4-methylenedioxymethamphetamine (MDMA) on functional connectivity (FC) using a novel multimodal method...
Neuroscience and Biobehavioral Reviews
April 1, 2019
Federico Turkheimer, Peter J. Hellyer, Angie A. Kehagia et al.
The concept of "emergence" has become commonplace in the modelling of complex systems, both natural and man-made; a functional property" emerges" from a system when it cannot be readily explained by the properties of the system's sub-units. A bewildering array of adaptive and sophisticated behaviours can be observed from large ensembles of elementary agents such as ant colonies, bird flocks or...
PLoS Computational Biology
August 24, 2017
Peter J. Hellyer, Claudia Clopath, Angie A. Kehagia et al.
21 citations
In recent years, there have been many computational simulations of spontaneous neural dynamics. Here, we describe a simple model of spontaneous neural dynamics that controls an agent moving in a simple virtual environment. These dynamics generate interesting brain-environment feedback interactions that rapidly destabilize neural and behavioral dynamics demonstrating the need for homeostatic...
Neuroscience & Biobehavioral Reviews
May 5, 2015
Federico Turkheimer, Robert Leech, Paul Expert et al.
64 citations
A variety of anatomical and physiological evidence suggests that the brain performs computations using motifs that are repeated across species, brain areas, and modalities. The computational architecture of cortex, for example, is very similar from one area to another and the types, arrangements, and connections of cortical neurons are highly stereotyped. This supports the idea that each...
Journal of The Royal Society Interface
October 29, 2014
Giovanni Petri, Paul Expert, Federico Turkheimer et al.
689 citations
Networks, as efficient representations of complex systems, have appealed to scientists for a long time and now permeate many areas of science, including neuroimaging (Bullmore and Sporns 2009 Nat. Rev. Neurosci. 10 , 186–198. ( doi:10.1038/nrn2618 )). Traditionally, the structure of complex networks has been studied through their statistical properties and metrics concerned with node and link...