Research published in Multiple sclerosis and related disorders

Effectiveness and safety of ofatumumab in treatment-naive and oral DMT-switched multiple sclerosis patients: a multicenter observational study in China.

Multiple sclerosis and related disorders November 1, 2025 Yang Yang, Xinyi Duan, Jing Wang et al. 1 citation

Ofatumumab, a fully humanized anti-CD20 monoclonal antibody, is the only highly effective disease modifying therapy (DMT) approved for the treatment of relapsing multiple sclerosis (RMS) in China up to data. Real-world data are necessary to investigate the factors for switching from oral DMTs and to assess the effectiveness and safety of ofatumumab in the Chinese MS population. We conducted a...

DOI: 10.1016/j.msard.2025.106827 Full text Multiple sclerosis Ofatumumab Real-world data Switch +2

A supplementary training program integrating cold exposure, breathing exercises and mindfulness as a complementary treatment for neuropsychological aspects of multiple sclerosis - a pilot interventional study.

Multiple sclerosis and related disorders July 1, 2025 Darina Slezáková, Louise Mária Adamová, Peter Marček et al. 3 citations

Most of the patients with multiple sclerosis (MS) suffer from cognitive impairment, fatigue and/or mood disturbances. These symptoms are usually resistant to both disease-modifying and symptomatic treatment. Since there is a trend to a holistic approach to MS patients, we aimed to confirm the effect of combined cold exposure, controlled breathing and mindfulness - Wim Hof Method (WHM) - on...

DOI: 10.1016/j.msard.2025.106450 Full text Mindfulness Breathing exercises Cold exposure Complementary treatment +3

Assessing the landscape and charting paths: UK neurology trainees' opinions on neuroinflammation subspecialty.

Multiple sclerosis and related disorders December 1, 2024 Tarunya Arun, Kate Petheram, Emma Tallantyre et al.

Therapeutics of neuroinflammatory disorders including multiple sclerosis is one of the fastest growing areas in neurology. However, pressures on higher specialty training in neurology together with an expanding curriculum have led to challenges in adequately preparing trainees for a subspecialist career. In this study we set out to understand current perceptions and barriers to training in...

DOI: 10.1016/j.msard.2024.106144 Full text DMT Medical-education Neurological-training Multiple-sclerosis-care +6

Feasibility and efficacy of an at-home, smart-device aided mindfulness program in people with Multiple Sclerosis.

Multiple sclerosis and related disorders October 2023 Francesco Motolese, Domenica Stelitano, Jacopo Lanzone et al.

Multiple Sclerosis (MS) is a chronic disease with a high prevalence of neuropsychiatric symptoms. Mindfulness is a practice that encourages individuals to cultivate a present-focused, acceptance-based approach for managing psychological distress. Its positive effect on MS has been demonstrated, but learning such technique is expensive and time-consuming. In this study, we investigated the...

DOI: 10.1016/j.msard.2023.104931 Full text Mindfulness Biofeedback devices EEG Multiple sclerosis +2

Effects of Acceptance and Commitment Therapy (ACT) and Mindfulness-Based Stress Reduction (MBSR) on symptoms and emotional competencies in individuals with multiple sclerosis.

Multiple sclerosis and related disorders November 2022 Dena Sadeghi-Bahmani, Leila Esmaeili, Faezeh Mokhtari et al.

Compared to the general population, individuals with multiple sclerosis (MS) report higher levels of insomnia, depression, fatigue, and paresthesia, and lower levels of emotional competencies (understanding emotions in self and others). Available treatments are limited, and novel approaches to reducing symptoms and enhancing emotional competencies in MS are needed. Two potentially beneficial...

DOI: 10.1016/j.msard.2022.104029 Full text Depression Emotional competencies Fatigue Insomnia +2

Undertaking specific stress-reducing activities are associated with reduced fatigue and depression, and increased mastery, in people with multiple sclerosis.

Multiple sclerosis and related disorders June 2022 Nupur Nag, Xirun Yang, George Jelinek et al.

Multiple sclerosis is a demyelinating autoimmune disease, presenting with heterogenous symptoms that impact daily living. Undertaking stress-reducing activities may reduce symptoms including depression and fatigue, and enhance mastery, the sense of control of one's life. We assessed cross-sectional associations of undertaking stress-reducing activities or meditation on depression, fatigue, and...

DOI: 10.1016/j.msard.2022.103804 Full text Multiple sclerosis, meditation

Trait mindfulness, emotion dysregulation, and depression in individuals with multiple sclerosis.

Multiple sclerosis and related disorders February 1, 2022 E. Duraney, B. Schirda, J. Nicholas et al.

OBJECTIVES Emotion dysregulation plays a role in the development and maintenance of psychopathology. Given the higher rates of mood disturbances in people with multiple sclerosis (PwMS), there is a need to explore the relationships between metrics of emotion dysregulation and potential protective traits. Mindfulness, a multi-faceted trait characteristic reflecting present moment awareness, is...

DOI: 10.1016/j.msard.2022.103651

A systematic review of the effects of cannabis on cognition in people with multiple sclerosis.

Multiple sclerosis and related disorders October 1, 2021 Jeffrey Landrigan, Kitti Bessenyei, Damian Leitner et al.

BACKGROUND Multiple sclerosis (MS) is a chronic demyelinating disease which leads to sensory, motor, autonomic, and cognitive symptoms. Cannabis is a common way for persons with MS (pwMS) to seek symptomatic therapy. Given the capacity for both cannabis and MS to cause cognitive impairment, it is important to determine whether there is any negative impact when the two co-occur. The objective of...

DOI: 10.1016/j.msard.2021.103338

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