Religions
June 12, 2026
Yue Wang
This article argues that lotus and dharma wheel motifs in the Dunhuang Mogao Caves function not merely as decorative symbols but as active visual apparatuses that generate embodied religious experience through a mechanism we term “totemic mediation.” Drawing on Lévi-Strauss’s structuralist reading of totemism, Descola’s ontological framework, Gell’s theory of art as agency, Meyer’s “sensational...
Nature Communications
May 29, 2026
Yuxi Zhao, Chanjuan Xu, Yue Wang et al.
The κ-opioid receptor (κOR) represents a promising non-addictive analgesic target due to its critical role in pain and reward pathways. Despite evidence of κOR dimerization, its molecular basis and pharmacological significance remain elusive. Here, we demonstrate stable κOR dimer formation in living cells and present cryo-electron microscopy structures of salvinorin A-bound κOR dimer complexed...
Neuroimage
December 15, 2025
Qingyan Kong, Yue Wang, Min Li et al.
Flow is a deeply immersive state that supports optimal performance, yet its neural basis under conditions of real-world expertise remains poorly understood. Using functional MRI, this study investigated how long-term Chinese calligraphy expertise relates to flow in a culturally meaningful setting. Expert and novice participants performed imagined embodied handwriting of Kai-Shu and Cao-Shu,...
Journal of Affective Disorders
January 15, 2025
Qiongyao Yang, Yitan Yao, Xiaoping Yuan et al.
3 citations
Subanesthetic ketamine is a rapidly acting antidepressant, yet the effects of ketamine on cognitive function are inconsistent. The primary objective of this study was to explore the effects of esketamine on memory function and plasma levels of nerve growth factor (NGF) in patients with depression. A total of 132 patients with depression completed six intravenous esketamine infusions (0.4 mg/kg)...
Neuron
October 9, 2024
Luyu Fan, Youwen Zhuang, Hongyu Wu et al.
6 citations
Understanding the kinetics of LSD in receptors and subsequent induced signaling is crucial for comprehending both the psychoactive and therapeutic effects of LSD. Despite extensive research on LSD's interactions with serotonin 2A and 2B receptors, its behavior on other targets, including dopamine receptors, has remained elusive. Here, we present cryo-EM structures of LSD/PF6142-bound dopamine...
European Archives of Psychiatry and Clinical Neuroscience
September 28, 2024
Yue Wang, Qiongyao Yang, Chuanchuan Chen et al.
10 citations
Anhedonia, defined as a significant loss of interest or pleasure, is one of the core symptoms of treatment- resistant depression (TRD) and is often associated with poor prognosis. This article primarily investigates the changes in anhedonia symptoms, inflammatory markers, and cortisol levels in TRD patients after low-dose esketamine treatments. A total of sixty patients with TRD were enrolled...
International Journal of Environmental Research and Public Health
December 4, 2022
Yue Wang, Zexin Zheng, Xiaoyi Duan et al.
18 citations
Social adaptation of migrant children is not only related to the physical and mental health and development of individuals, but also reflects the level of urban social integration and stable development. Mindfulness has a protective effect on individual social adaptation. Self-esteem and resilience were found to be positively associated with mindfulness and social adaptation. Based on the...
Frontiers in Psychiatry
November 14, 2022
Ying Li, Gui-Ping Qu, Huiyan Kong et al.
Background The outbreak of COVID-19 had a widely negative effect on adolescents’ academics, stress, and mental health. At a critical period of cortical development, adolescents’ cognition levels are highly developed, while the ability of emotion control is not developed at the same pace. Faced with negative emotions such as stress and social loneliness caused by COVID-19, adolescents’ “hot”...
Frontiers in Pharmacology
February 6, 2020
Shan Li, Xiaoxiao Luo, Dongyu Hua et al.
Patients are more likely to suffer from central nervous system (CNS) complications after anesthesia and surgery. However, postoperative depression (POD) has not yet received sufficient attentions, and its pathogenesis and therapeutic strategies remain poorly understood. We here aimed to investigate whether brain derived neurotrophic factor (BDNF)-tropomyosin-related kinase B (TrkB) signaling...