Elife
October 13, 2025
Guylaine Hoffner, Pablo Castro, Lynn Uhrig et al.
The resting primate brain is traversed by spontaneous functional connectivity patterns that show striking differences between conscious and unconscious states. Transcranial direct current stimulation (tDCS), a non-invasive neuromodulatory technique, can improve signs of consciousness in disorders of consciousness (DOCs); however, can it influence both conscious and unconscious dynamic...
arXiv Preprint Archive
October 7, 2025
Maria V. Sanchez-Vives, Arnau Manasanch, Andrea Pigorini et al.
The cerebral cortex spontaneously displays different patterns of activity that evolve over time according to the brain state. Sleep, wakefulness, resting states, and attention are examples of a wide spectrum of physiological states that can be sustained by the same structural network. Furthermore, additional states are generated by drugs (e.g., different levels of anesthesia) or by pathological...
Communications Biology
September 30, 2024
Pablo Castro, Andrea I. Luppi, Enzo Tagliazucchi et al.
21 citations
Resting-state functional magnetic resonance imaging evolves through a repertoire of functional connectivity patterns which might reflect ongoing cognition, as well as the contents of conscious awareness. We investigated whether the dynamic exploration of these states can provide robust and generalizable markers for the state of consciousness in human participants, across loss of consciousness...
Nature Communications
March 11, 2024
Andrea I. Luppi, Lynn Uhrig, Jordy Tasserie et al.
43 citations
A central challenge of neuroscience is to elucidate how brain function supports consciousness. Here, we combine the specificity of focal deep brain stimulation with fMRI coverage of the entire cortex, in awake and anaesthetised non-human primates. During propofol, sevoflurane, or ketamine anaesthesia, and subsequent restoration of responsiveness by electrical stimulation of the central...
bioRxiv (Cold Spring Harbor Laboratory)
May 18, 2023
David Aquilué-Llorens, Jennifer S. Goldman, Alain Destexhe
2 citations
preprint
ABSTRACT Biophysically-grounded whole-brain models were built recently using tractography data to interconnect multiple mesoscopic models, which can simulate the dynamics of neuronal populations with only a few equations. Mean-field models of neural populations, specifically the Adapting AdEx mean-field, was used for this purpose because it can integrate key biophysical mechanisms such as...