Catecholamines and Behavior · 1
1975
Arnold J. Friedhoff, Jack W. Schweitzer
1 citation
Normal mental functions can be disrupted by many kinds of drugs. Hallucinogens are of special interest because of their ability to impair higher centers without producing substantial effect on other functions of the central nervous system. While the mechanism of action of hallucinogens has not been clarified, the striking structural resemblance between certain of these agents and several...
Journal of Neurochemistry
October 1, 1972
D. G. Grahame‐Smitha
Abstract— In rats treated with a monoamine oxidase inhibitor, (tranylcypromine), L‐ tryptophan produces a stereotyped syndrome of hyperactivity and hyperpyrexia due to an increased rate of brain serotonin (5‐hydroxytryptamine) synthesis. Pretreatment of rats with intraperitoneal injections of cycloheximide, acetoxycycloheximide, emetine and dehydroemetine and of mice with puromycin inhibited...
Planta Medica
March 1, 1972
S. P. Ghosal
8 citations
Over two dozen Indian medicinal plants belonging to the families Leguminosae, Gramineae, and Malpighiaceae have been screened for potential psychodelic substances. The evaluation of only the indole bearing plants is reported here. Localization of about forty indole alkaloids, representing four broad structural types, viz., indole–3–alkylamines, carboxylated tryptamines, β–carbolines, and...
British Journal of Pharmacology
December 1, 1971
C. M. Bradshaw, M.h.t. Roberts, E. Szabadi
16 citations
The effects of mescaline upon single cortical neurones were studied, using the microiontophoretic technique. Mescaline elicited excitatory and depressant responses similar to those evoked by noradrenaline (NA) and 5-hydroxytryptamine (5-HI). The responses to NA and mescaline were usually in the same direction, the neurone being either excited by both drugs or depressed by both drugs. The...
Planta Medica
February 1, 1971
S. Ghosal, Saumitra Sen Singh, S. Bhattacharya
39 citations
Four indole–3–alkylamines, viz., N,N–dimethyltryptamine, its N b –oxide, bufo–tenine, and 5–methoxy–N,N–dimethyltryptamine along with two uncharacterized 5–oxy–indole–3–alkylamines and a β–carboline were isolated from the various parts, except the trichomes of pods, of Mucuna pruriens DC. The trichomes of pods afforded only serotonin. Besides these, choline was found in all parts of the plant....
Journal of Pharmacy and Pharmacology
September 1, 1963
A Chodera
Abstract The effects of two lysergic acid derivatives, 2-bromlysergic acid diethylamide ‘BOL 148’ and 1-methyl-lysergic acid butanolamide ‘UML 491’ on the antidiuresis induced by 5-hydroxytryptamine ‘5-HT’ has been studied in rats given a dose of 1 mg./kg. 5-HT subcutaneously. BOL 148, 5 mg./kg., and UML 491, 2·5 mg./kg., counteracted the induced antidiuresis. By contrast, the antidiuretic...
JAMA
July 14, 1962
Sidney Cohen
65 citations
TWO DECADES AGO Hofmann ' accidentally discovered the hallucinogenic activity of d-lysergic acid diethylamide (LSD-25). Its ability to induce a model psychosis makes it an excellent laboratory device for the study of psychotic-like phenomena. LSD-25 has also been employed as an adjunct to psychotherapy because recall of repressed memories is enhanced and ego defensiveness to conflict laden...
Journal of Mental Science
April 1, 1960
John Smythies, Carmit Levy
23 citations
There are, in the main, two principal methods of biological research into the problem of causation of schizophrenia. In the first, or direct method, studies are made of the body fluids and of the metabolism of schizophrenics in the hope of turning up some toxic factor or error of metabolism. Such studies are currently under way in a number of centres and, although many claims as to positive...
American Journal of Physiology-Legacy Content
December 1, 1959
J. Paul Mcneill, John K. Hampton
3 citations
Rats were injected intramuscularly with 5-HT or LSD and intravenously with 5-HT, LSD, BOL or equimolar concentrations of 5-HT + LSD or 5-HT + BOL. Appropriate saline controls were included. They were then exposed to a standard amount of Noble-Collip trauma. Animals receiving 5-HT i.m. showed a significant multiphasic mortality curve after trauma depending on dose of drug. With small doses,...
Experimental Biology and Medicine
July 1, 1958
Nicholas P. Plotnikoff, Helen Washington
7 citations
1. It has been demonstrated that chlorpromazine, perphenazine, proclorperazine, promazine, thiopropazate, promethazine and reserpine are effective antagonists of mescaline-induced mortality in CF1 mice. 2. No significant protection was found with use of sodium phenobarbital, meprobamate, benactyzine, atropine, hydroxyzine, ethoxybutamoxane, SY-21, diphenylhydantoin, trimethadione, lysergic acid...