Neuroendocrinology
March 26, 2008
Anni Sietnieks, Bengt J. Meyerson
11 citations
Copulatory behavior in the ovariectomized rat, i.e. the lordosis response (LR) on being mounted by a male, can be induced by administration of either estrogen alone or estrogen followed by progesterone. LR has been shown to be inhibited by lysergic acid diethylamide (LSD) in certain doses (≥50 μg/kg) and by Levo-5-hydroxytryptophan (L-5-HTP) (≥2.5 mg/kg). This effect was recently found to be...
Neuroscience
March 3, 2008
A R Alvaro, J Martins, A C Costa et al.
Ecstasy (3,4-methylenedioxymethamphetamine; MDMA) has potent CNS stimulant effects. Besides the acute effects of MDMA, such as psychomotor activation, euphoria, decreased appetite, and hyperthermia, long-term damage of dopaminergic and serotonergic nerve terminals in multiple brain areas have also been reported. Although some studies have demonstrated that considerable amounts of MDMA reach the...
Behavioural Pharmacology
March 2008
Matthew R. Skelton, Michael T. Williams, Charles V. Vorhees
+/-3,4-Methylenedioxymethamphetamine (MDMA) is a chemical derivative of amphetamine that has become a popular drug of abuse and has been shown to deplete serotonin in the brains of users and animals exposed to it. To date, most studies have investigated the effects of MDMA on adult animals. With a majority of users of MDMA being young adults, the chances of the users becoming pregnant and...
Das Gesundheitswesen
March 1, 2008
Yehonala Gudlowski
Psychosen sind Störungen der Neurotransmission im Gehirn. Bestimmte Neurotransmitter (z.B. Dopamin, Serotonin und Glutamat) werden in bestimmten Hirnregionen zu viel, in anderen zu wenig ausgeschüttet, so dass es zu Störungen des Denkens, der Handlungsplanung und der sensorischen Wahrnehmung (Halluzinationen) kommt oder bestimmte Ereignisse in bizarrer Weise interpretiert werden. So kann beim...
Psychopharmacology
March 2008
Sami Ben Hamida, Erin Plute, Brigitte Cosquer et al.
(+/-)-3,4-methylenedioxymethamphetamine (MDMA, ecstasy) is often taken recreationally with ethanol (EtOH). In rats, EtOH may potentiate MDMA-induced hyperactivity, but attenuate hyperthermia. Experiment 1 compared the interactions between EtOH (1.5 g/kg) and MDMA (6.6 mg/kg) with EtOH + cocaine (COCA; 10 mg/kg) and EtOH + amphetamine (AMPH; 1 mg/kg) on locomotor activity and thermoregulation....
February 25, 2008
Melissa Medrano Gomes
1 citation
cromatografia líquida de alta eficiência H 2 O 2 : peróxido de hidrogênio HRP: horseradish peroxidase 5-HT: 5-hidroxitriptamina (serotonina)
Journal of Pharmacology and Experimental Therapeutics
February 1, 2008
Jun-Xu Li, Kenner C Rice, Charles P France
51 citations
Discriminative stimulus effects of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM) and related drugs have been studied extensively in rodents, although the generality of those findings across species is not known. The goals of this study were to see whether monkeys could discriminate DOM and to characterize the DOM discriminative stimulus by studying a variety of drugs, including those...
Journal of Psychopharmacology
January 21, 2008
Susana de Sola Llopis, Mónica Miguélez-Pan, Jordi Peña‐Casanova et al.
58 citations
There is important preclinical evidence of long lasting neurotoxic and selective effects of ecstasy MDMA on serotonin systems in non-human primates. In humans long-term recreational use of ecstasy has been mainly associated with learning and memory impairments. The aim of the present study was to investigate the neuropsychological profile associated with ecstasy use within recreational polydrug...
Pharmacology, Biochemistry, and Behavior
January 2008
Jerrold C Winter
It has been observed that agents with agonist activity at 5-HT2A receptors prevent neurotoxicity induced by the non-competitive NMDA antagonist, dizocilpine (MK-801). Subsequent behavioral studies reported complete antagonism by LSD and DOM of the stimulus effects of the related NMDA antagonist, phencyclidine [PCP]. The present study sought to extend those observations to include other...
Journal of Pharmacological Sciences
2008
Takayuki Nakagawa, Shuji Kaneko
44 citations
Psychostimulants including amphetamines and cocaine, opioids including morphine, and some recreational drugs share the ability to cause drug dependence and addiction. Although these drugs of abuse primarily act on distinct molecular targets, such as monoamine transporters or receptors, they finally converge to common neural pathways. Several lines of evidence suggest that their chronic...