Previous research indicated that the prevalence of frequent nightmares and/or the presence of a nightmare disorder is quite high in patients with mental disorders. In the present study, 75 randomly selected psychiatric inpatients were interviewed and completed questionnaires regarding nightmares, sleep, and psychopathology. The percentage of patients with nightmares once per week or more often...
3,4-Methylenedioxymethamphetamine (MDMA, Ecstasy) is a recreational drug under clinical investigation for the treatment of central nervous system disorders, including post-traumatic stress disorder. Chemical synthesis of MDMA mainly relies on the use of safrole and piperonal as starting materials. We report a novel strategy integrating bioconversion and biocatalysis in the bioproduction of MDMA...
The objective of this study was to evaluate the effectiveness of a shortened version of Mindfulness-integrated Cognitive Behavior Therapy (MiCBT) in managing pain and psychological distress (including depression, anxiety, and stress), improving equanimity, hope, and post-traumatic growth in patients with Stage I-III breast cancer undergoing chemotherapy. A total of 42 women were randomly...
Black Americans are significantly underrepresented in psychedelic trials despite significant mental health disparities. Growing research suggests that psychedelic-assisted therapy (PAT) is an effective treatment for post-traumatic stress disorder and depression. It is important to understand perceptions of PAT among populations with unmet mental health needs. We conducted four focus groups to...
This study examined patient perspectives on psilocybin therapy, specifically their acceptance and views on the therapeutic benefits of both hallucinogenic and non-hallucinogenic forms. A cross-sectional survey was conducted among psychiatric patients aged 18-65 at a community mental health center, assessing their attitudes, knowledge, and acceptance of psilocybin therapy. In total, 62.4% of the...
PT may hold promise not only in the treatment of eating disorders but also trauma-related disorders, including PTSD and dissociative amnesia. Potential mechanisms of psilocybin's facilitation of remembering and processing traumatic material is reviewed.
Psychedelics show promise in treating depression, PTSD, and substance use disorder, prompting research into their mechanisms of action. Most studies use rodent models, but genetic tools can be challenging to apply. Invertebrate models, like C. elegans , offer a cost-effective alternative with short generation times and genetic tractability. This study examined the worm's response to the...
Abstract Nightmare disorder is a rapid-eye-movement (REM) parasomnia provoking disturbing oneiric activity and significant distress. This chapter provides a comprehensive overview of the diagnostic criteria and definition of this sleep disorder. The authors reviewed findings on neural correlates of nightmares, also examining the changes over the life span. They describe the most common comorbid...
Tecnología en MarchaMay 20, 2025Frank Barrientos-Alfaro, Valeria Herrera-Rojas, Michelle Montero-Quesada et al.
Los hongos juegan un papel clave en el mantenimiento de la vida en la tierra, ya que desempeñan múltiples funciones a nivel ecológico. Adicionalmente, son productores de diversos metabolitos secundarios, entre estos, los alcaloides, los cuales en ciertos casos pueden proveer propiedades alucinógenas. Psilocybe cubensis es una especie común de hongos alucinógenos conocida como “hongos mágicos”....
SleepMay 19, 2025Emily Feldman, Rebecca Essien, Danya Husein et al.
Abstract Introduction Dream recall frequency (DRF), or how often individuals remember and report dreams, is influenced by factors such as family dynamics, mental health, and cultural norms. Women tend to report higher DRF and greater distress from nightmares, while individuals with psychiatric conditions often exhibit reduced DRF. This study examined the relative contributions of childhood...