A robust body of research has linked nightmares to suicide. For example, research has found that nightmares predict suicidal ideation above and beyond other mental health symptoms (such as depression and post-traumatic stress disorder) and that treating nightmares may indirectly decrease the risk of suicide. Considering the established link between nightmares and suicide, our goal was to...
SleepMay 1, 2025Zachary Sherman, Albert Vacheron, Rabin Shrestha et al.
Trauma-associated sleep disorder (TASD) is a proposed parasomnia that, while sharing criteria with REM-behavior disorder (RBD) remains under-recognized by clinicians. It is more common in the veteran population, and lacks clear guidelines on treatment, especially when accompanied by dream enactment behavior. A 67 year-old Gulf War veteran presented to sleep clinic with over 30 years of frequent...
Background: Patients with refractory conditions often identify themselves with their illness, which affects multiple aspects of their lives. The pictorial representation of illness and self measure (PRISM) is a tool used to assess the enmeshment of individuals' perception of self with a particular medical condition, broadly termed self-condition enmeshment. Aims: This study aimed to evaluate...
Abstract This is the first book to explore the use of psychedelic medicines in palliative care and addiction medicine. Bringing together a diverse team of palliative physicians, therapists, researchers, spiritual guides, and entrepreneurs, the book explores the history, cultural significance, science, and legal status of eight major psychedelic medications. Each medication holds fascinating...
May 1, 2025Angelica Ukaigwe, Abhishek Chauhan, S. Vinod Kumar
Abstract 5-Methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is a psychoactive compound found in the parotid gland venom of the Sonoran Desert toad, Incilius alvarius, and certain seeds, leaves, and barks within the Amazonian rainforest. Similar to DMT containing ayahuasca, 5-MeO-DMT has become newly integrated as a spiritual sacrament in certain churches, offering a psychedelic experience to process...
Neurobiology of StressMay 1, 2025Alanna Kit, Kate Conway, Savannah Makarowski et al.5 citations
There is growing interest in exploring the therapeutic potential and mechanisms of action of psilocybin on stress-related neuropsychiatric disorders, including depression, generalized anxiety disorder (GAD), post-traumatic stress disorder (PTSD), obsessive-compulsive disorder (OCD), addiction, and disordered eating. Despite promising progressions in preclinical and clinical research, the...
Female prisoners in Latin America experience significantly higher rates of mental health issues compared to their male counterparts. The most prevalent include anxiety and stress, which stem from feelings of insecurity, perceived failure, long periods of detention, and the inability to care for their children. Furthermore, over 50% of female prisoners have been exposed to traumatic events,...
Psychedelics, such as psilocybin and lysergic acid diethylamide, modulate neuroplasticity and brain connectivity via 5-HT2A receptors. Their efficacy has been demonstrated in depression and anxiety, where they are particularly interesting because of their rapid and long-lasting effect. They could also be beneficial for addictions, post-traumatic stress, and obsessive-compulsive disorder. This...
Psychedelic compounds have demonstrated remarkable therapeutic potential for treating neuropsychiatric disorders by promoting sustained neuroplasticity in the prefrontal cortex (PFC). Cognitive flexibility-the ability to adapt previously learned rules to novel situations-represents a critical PFC function that is frequently impaired in depression, PTSD, and neurodegenerative conditions. In this...
Introduction: Ketamine is an evidenced-based treatment for depression, and it has shown promise in addressing many other mental health conditions related to work-related stress or burnout, such as anxiety and post-traumatic stress disorder. Ketamine-assisted psychotherapy (KAP) is part of an emerging model of psychedelic medicine that employs psychoactive agents to support the psychotherapeutic...