INTRODUCTION: After decades of regulatory marginalization, psychedelic compounds have reemerged as promising therapeutic tools in psychiatry, driven by unmet clinical needs in treatment-resistant mental disorders and by growing evidence of rapid and sustained effects on mood, cognition, and behavior. AREAS COVERED: This narrative review critically examined the current clinical and regulatory...
I kølvandet på 20 års borgerkrig i det nordlige Uganda fulgte en bølge af traumer, onde ånder og vold, som fortsat forpester livet og fordrer handling. Brutaliteten og de mange ubegravede lig som krigen efterlod, opleves af mange som årsag til forskellige former for åndelig og social kontaminering. I en biomedicinsk forståelse beskrives forstyrrelserne som Post Traumatisk Stress Syndrom (PTSD),...
Psilocybin, N,N-dimethyltryptamine (DMT), lysergic acid diethylamide (LSD), and 3,4-methylenedioxymethamphetamine (MDMA) are psychedelic compounds with therapeutic potential for depression, anxiety, and post-traumatic stress. However, their relevance to endurance athletes, who face particular psychological and physical stressors, remains underexplored. This study combines a conceptual overview...
OUTRAS PALAVRASMarch 18, 2026Gabriela Marques Guimarães Simão, Isabella Andrade Santana, Luiza Paulone Santos Fortunato Dias et al.
O presente estudo aborda o potencial terapêutico dos psicodélicos no tratamento de distúrbios neuropsiquiátricos, destacando sua relevância em um contexto de crescente prevalência de condições como depressão, ansiedade e transtorno de estresse pós-traumático. O objetivo principal é investigar as propriedades farmacológicas desses compostos, seus mecanismos de ação e os resultados clínicos...
Firefighters face significant inherent risks which leads to an increase in mental health problems such as post-traumatic stress disorder (PTSD), anxiety, and depression. The mental health challenges have negative impacts both on their personal health and their professional performance which results in higher staff turnover rates. This research proposes an innovative conceptual framework that...
Yoga, an ancient mind-body practice originating from India, has gained recognition as a complementary intervention for managing psychiatric disorders. Derived from the Sanskrit term “Yuj,” meaning “to unite,” yoga integrates physical postures (asanas), breath regulation (pranayama), and meditation (dhyana) to promote harmony between body, mind, and spirit. Unlike conventional exercise, yoga...
psychiatric disorders, beta-carbolines, trace amine, phosphoproteomics, social hierarchy. Scientific interest in psychedelic substances has re-emerged, offering new perspectives on the treatment of neuropsychiatric and neurological disorders.Historically, psychedelics have been associated with a wide spectrum of positive and negative effects, encompassing ritualistic and spiritual use,...
Aims The recent regulatory approval of esketamine in adults heralded the renaissance of research into psychedelic compounds. However, the relevance of this resurgence for children and adolescents remains unclear. This review examines the rationale for investigating psychedelics in pediatric psychopharmacology. Methods We reviewed recent literature, regulatory documents, and clinical trial...
Introdução: Os transtornos psiquiátricos representam um importante desafio na saúde pública mundial, com impacto significativo na qualidade de vida, funcionalidade e mortalidade dos pacientes. Embora os psicofármacos tradicionais, como antidepressivos, antipsicóticos e estabilizadores de humor sejam amplamente utilizados, muitos indivíduos apresentam resposta insatisfatória, falha terapêutica...
Psychedelic compounds such as psilocybin, Lysergic Acid Diethylamide (LSD), N,Ndimethyltryptamine (DMT), and 3,4-methylenedioxymethamphetamine (MDMA) are emerging as novel therapeutics for neuropsychiatric disorders, including depression, Post-Traumatic Stress Disorder (PTSD), and addiction. Acting primarily through serotonin 5-HT2A receptor agonism, they activate intracellular cascades...