L'EncephaleAugust 1, 2025Yara Bachir, Raymond Kassab, C. Hallal et al.
OBJECTIVE This case report explores the efficacy of intravenous Ketamine in treating active suicidal ideation in a 24-year-old female with comorbid major depressive disorder (MDD), borderline personality disorder (BPD), posttraumatic stress disorder (PTSD), and functional neurological disorder (FND). CASE DESCRIPTION The patient, with a history of multiple suicide attempts and...
Breathwork - deliberately altering the way one breathes - has gained growing attention as an emerging non-pharmacological intervention for mental health and stress regulation. A novel yet ancient method that remains largely underexplored in the literature, breathwork requires structured, evidence-based investigation to optimize its application. This review analyses the existing literature on...
Mystical experiences are powerful experiences that may have therapeutic value. Ketamine, a dissociative anesthetic, has shown potential to induce mystical experiences. However, little research has explored this phenomenon, particularly in treatment-resistant depression. We analyzed clinical data from 60 veterans with treatment-resistant depression receiving a total of 189 ketamine treatments....
Abstract Background Psychedelics have long been explored as potential treatments for mental illnesses. Since the mid-20th century, clinical trials of psychedelics such as LSD for depression and anxiety in terminally ill patients have been conducted. In the 21st century, revived and accelerated efforts to promote the proper use of psychedelics in the medical field have led to increasingly...
Background: Child abuse is a widespread issue affecting millions of children worldwide. It can take the form of physical, emotional, or sexual abuse and often leads to lasting psychological harm. Addressing the emotional and mental health needs of survivors is crucial for their long-term well-being. This study explores how Buddhist meditation can help promote psychological healing and...
OBJECTIVE: This review explores ketamine's expanding role in managing both chronic pain and mental health conditions, focusing on its pharmacologic mechanisms, clinical applications, and therapeutic potential. We assess its analgesic properties, FDA-approved application in the form of Spravato (esketamine) for depression, and off-label use for analgesia and psychiatric disorders. METHODS: A...
There are few effective treatments for eating disorders (EDs), and new interventions are urgently needed. The MEDication and other drugs For Eating Disorders ("MED-FED") survey investigated the lived experience of adults with EDs regarding their prescription and non-prescription drugs use. Psychedelic drugs were highly rated in this survey for their impact on ED symptoms and general mental...
A revolutionary change in contemporary therapeutic paradigms may be seen in the renewed interest in psychedelic plant remedies. Psychedelic plants like psilocybe mushrooms, ayahuasca, iboga, and salvia divinorum, which have long been valued for their spiritual and therapeutic qualities in a variety of cultures, are now the subject of intense scientific research. According to recent clinical...
Sleep Paralysis (SP) is a complex and multifaceted phenomenon situated at the intersection of neurobiology, psychiatry, genetics, and cultural belief systems. This study offers a comprehensive investigation into SP, integrating findings from neurophysiological, psychological, and sociocultural domains. Neurobiological evidence highlights disruptions during the rapid eye movement (REM) sleep...
Background: Contemplative practices encompass a variety of static and dynamic practices. A theoretical introduction traces differences among contemplative and meditative states; bottom-up and top-down embodied contemplative practices; implications of polyvagal theory in trauma recovery. Contemplative practices, by fostering insights, heightened awareness, and a deeper connection to a broader...