Journal of Clinical Sleep Medicine
September 1, 2025
Anthony N Reffi, David A Kalmbach, Philip Cheng et al.
Study objectives: Patients with acute trauma are vulnerable to suicidality following hospitalization. Research suggests nightmares and insomnia may interact to potentiate suicidality, possibly due to nightmares worsening co-occurring insomnia. Nightmares and insomnia are common stress reactions to acute trauma and might compound suicide risk within acutely traumatized patients. We tested the...
The Journal of Clinical Psychiatry
September 1, 2025
Vania Modesto-Lowe, Deanna Sgambato, Pa-C Margaret Chaplin
To the Editor: Psychedelic-assisted therapy (PAT) combines psychedelics, such as psilocybin, with guided psychotherapeutic support. 1 These substances interact with patient's mindset ("set") and the surrounding environment ("setting"), 2 making the context of the experience a critical factor in therapeutic outcomes.As these substances gain recognition for their therapeutic potential, it is...
Scientific Reports
August 29, 2025
Abbie L Little, Malcolm Boyle
Paramedics worldwide have a higher prevalence of PTSD, anxiety, and depression than the general population. Paramedicine students predominately enter the profession without preventative techniques to manage stress, depression and fatigue. The objective of this study was to examine the effect of Transcendental Meditation (TM) on the well-being and resilience of paramedicine students. A pilot...
August 29, 2025
Romesha Uduwawela
<p><strong>Psilocybin, the psychoactive compound found in certain mushrooms, has gained increasing attention for its potential therapeutic applications in mental health treatment. While clinical research highlights its efficacy in alleviating mental disorders, such as depression, anxiety, PTSD, and substance use disorders, much remains to be known about the role of acute doses of psilocybin...
Pharmaceutical Science
August 27, 2025
Guilllermo Castaño-perez, Sara Isabel Castaño-ocampo
The resurgence of research on the use of psychedelic substances for the treatment of mental disorders and addictions has generated significant interest in the scientific and clinical communities. This chapter examines the current evidence on the efficacy, safety, and limitations of psychedelics in the treatment of these conditions. Studies investigating the use of psychedelics as monotherapy...
Psychedelics
August 26, 2025
Harriet de Wit
Professor Harriet de Wit, a pioneering researcher in psychoactive drugs at the University of Chicago, shares her remarkable 45-year scientific journey in this illuminating Genomic Press Interview. As Director of the Human Behavioral Pharmacology Laboratory and recipient of prestigious honors including the 2019 European Behavioral Pharmacology Society Distinguished Investigator Award, Dr. de Wit...
August 23, 2025
Joseph M. Diehl, M. Zachary Rosenthal
preprint
Psychedelic-assisted psychotherapy (PAP) has emerged as a promising intervention for conditions such as depression, PTSD, and substance use disorders by enhancing the therapeutic potential of psychedelics with structured psychological support during preparation, dosing, and integration phases. Despite encouraging trial results, evidence for therapeutic mechanisms and optimal frameworks for PAP...
Research Square
August 21, 2025
Ritchy Hodebourg, Lillian Duncan, Eric Dereschewitz et al.
preprint
The rising legal acceptance of cannabis and the high comorbidity between cannabis use disorder (CUD) and post-traumatic stress disorder (PTSD) highlight the importance of understanding how stress and cannabis influence the brain. We recently discovered that cannabis use promotes two PTSD-like symptoms: avoidance coping behaviors and the generalization of stress-coping responses to a neutral...
Research Square
August 21, 2025
Guy Simon, Nir Tadmor, Michael Skragge et al.
2 citations
preprint
Abstract This mixed-methods study investigated the relationship between recalled childhood trauma during psychedelic experiences and subsequent extended psychological difficulties. While psychedelics can facilitate emotional processing of autobiographical material, a minority experience adverse effects or re-traumatization when trauma resurfaces. Phase 1 surveyed 608 individuals who experienced...
PsyArXiv
August 20, 2025
Deepanshu Tomar
preprint
The Bi-Interpretive Mind Framework (BIMF) introduces a dual-system model of human cognition and consciousness, positing the coexistence of two interdependent subsystems: the Primary Mind (logical, conscious, reality-testing) and the Secondary Mind (intuitive, unconscious, biologically interpretive). Subjective experience is conceptualized as emerging from the “interpretive handshake” between...