The original MAPS manual for MDMA-assisted therapy (MDMA-AT) opened a therapeutic frontier for PTSD. However, it drew critique for concepts—such as “inner healing intelligence” – that originated in transpersonal traditions rather than academic or empirically grounded clinical models. While many patients found the therapies helpful, these constructs were difficult to interpret and standardize....
January 8, 2026Michael Esposito, Ana M Ortiz Bernal, Alan K. Davis et al.
preprint
Clinical trials using 5-MeO-DMT to treat various mental health conditions are currently underway, however research on 5-MeO-DMT use in humans is limited. To date, no scoping review of the published, peer-reviewed literature exists. The purpose of the present analysis is to examine the extent, range, and nature of peer-reviewed research on the use of 5-MeO-DMT in humans and, ultimately, to...
The lifetime prevalence of mood disorders such as major depressive disorder (MDD) is thought to approach up to 50% of the world's population. Traditionally, research into the mechanisms of these disorders has focused on neurotransmission, but emerging evidence highlights neuroimmune interactions-the molecular signaling between immune and brain cells-as key regulators of brain plasticity,...
Introduction: Police personnel face high levels of stress and anxiety due to their exposure to traumatic and life-threatening situations. While traditional interventions are common, yoga has emerged as a promising alternative for mitigating stress and anxiety. This paper systematically reviews literature on the effectiveness of yoga-based interventions for police personnel, focusing on...
Aims: This study of people with motor neurone disease (MND) and caregivers examined how baseline levels of psychological distress influenced engagement with and psychological responses to a mindfulness intervention. This was with a view to guiding how services can best target mindfulness programs. Methods: Forty participants completed an MND-adapted four-session mindfulness-based stress...
The clinical use of psychedelic substances and Psychedelic-Assisted Therapy (PAT) is an area of growing interest that also raises significant social concerns and controversy. Despite existing legal restrictions, empirical research on substances such as psilocybin, mescaline, MDMA, LSD, DMT, and ibogaine has been developing, particularly in the treatment of conditions such as treatment-resistant...
O presente artigo investiga a constituição ontológica necessária para a ocorrência do sofrimento transformacional, articulando os fenômenos de sintomas de estresse pós-traumático e crescimento pós-traumático com a recente fenomenologia da experiência de possibilidades. A questão central interroga como o ser humano deve estar ontologicamente constituído para que experiências disruptivas possam...
This article examines Tee Yod (Death Whisperer, 2023), a Thai horror film directed by Taweewat Watanawat, through the lens of Buddhist psychology of trauma. Departing from the conventions of the Nang Phi genre, Tee Yod reinterprets the ghost as a metaphor for intergenerational suffering and psychological distress within a Buddhist cosmological and moral framework. Drawing on Theravāda Buddhist...
Veterans face unique mental health challenges, including elevated rates of post-traumatic stress disorder (PTSD), depression, and anxiety, compounded by cultural barriers to traditional therapies. Mindfulness-Based Stress Reduction (MBSR) offers a trauma-informed, non-pharmacological intervention tailored to align with military values. This study employed a repeated-measures design with 4 time...
A recent randomized controlled trial (RCT) did not find an effect of imagery rehearsal therapy (IRT) for nightmares as an add-on to treatment as usual in a sample of trauma-affected refugees. However, certain factors may have accounted for substantial variations in treatment outcomes. This study aimed to test whether symptom severity, cognitive functioning, use of an interpreter, motivation for...