Neuron
January 7, 2026
Jinsu Lee, Michael A. Wheeler
The lifetime prevalence of mood disorders such as major depressive disorder (MDD) is thought to approach up to 50% of the world's population. Traditionally, research into the mechanisms of these disorders has focused on neurotransmission, but emerging evidence highlights neuroimmune interactions-the molecular signaling between immune and brain cells-as key regulators of brain plasticity,...
Psychedelics
May 6, 2025
Michael A. Wheeler
In a thought-provoking Genomic Press interview, Dr. Michael Wheeler emerges as a brilliant scientific innovator at the intersection of neuroscience and immunology. As an Assistant Professor at Harvard Medical School and an investigator at Brigham and Women's Hospital, Wheeler's groundbreaking research explores how brain-immune communication shapes our behaviors and emotions. His innovative...
Nature
April 23, 2025
Elizabeth N. Chung, Jinsu Lee, C. Polonio et al.
Neuroimmune interactions—signals transmitted between immune and brain cells—regulate many aspects of tissue physiology1, including responses to psychological stress2, 3, 4–5, which can predispose individuals to develop neuropsychiatric diseases6, 7, 8–9. Still, the interactions between haematopoietic and brain-resident cells that influence complex behaviours are poorly understood. Here, we use...
Oxford Scholarship Online
June 21, 2018
Michael A. Wheeler
According to one prominent view in contemporary epistemology, the correct application of one’s cognitive abilities in believing truly is necessary and sufficient for a kind of credit that is, in turn, necessary for knowledge. Epistemologists who hold this view typically take the cognitive abilities concerned to be based in states and processes that are spatially located inside the head of the...
The MIT Press eBooks
May 21, 2010
Michael Wheeler
115 citations
This chapter aims to clarify the relationship between the extended cognition hypothesis (ExC) and functionalism, and to defend extended functionalism against three of its strongest criticisms. ExC claims that there are conditions under which thinking and thoughts are spatially distributed over the brain, body, and world in such a way that the external factors concerned are rightly accorded...