Despite clinical investigations with psychedelics for severe cases of mood disorders and PTSD and current research suggesting such applicability, research on their application in couples therapy and sex therapy is scarce. The objective of this systematic review was to highlight these drugs as adjuvants for such patients. Literature research was conducted using the terms “couple’s therapy” or...
PsychopharmacologyFebruary 1, 2026Savannah H M Lightfoot, Andrei S Nastase, Gabriela Costa Lenz Cesar et al.
Current treatment options for PTSD have unreliable efficacy, with many individuals unable to achieve complete remission. Cannabis and cannabinoids that act through the endogenous cannabinoid (endocannabinoid) system to help promote trauma recovery by means of enhanced extinction learning are potential therapeutic, pharmacological candidates. Using a preclinical model of translationally-relevant...
Zusammenfassung Psychedelika wie Psilocybin und LSD durchlaufen eine bemerkenswerte Geschichte, die von frühen psychiatrischen Anwendungen über den Freizeitgebrauch und die Prohibition in den 70er Jahre bis zur aktuellen Wiederentdeckung in klinischen Studien reicht. MDMA wird seit etwa 15 Jahren für die Behandlung der posttraumatischen Belastungsstörung evaluiert. In der Behandlung werden...
Psychedelic-assisted therapy (PAT) is increasingly investigated as a treatment for depression, post-traumatic stress disorder (PTSD), and substance use disorder. In the United States (US) and European Union, esketamine has been approved for the treatment of depression, while psilocybin and 3,4-methylenedioxymethamphetamine (MDMA) have received Breakthrough Therapy Designation in the US for...
BACKGROUND: Since Australia's Therapeutic Goods Administration down-scheduled two psychedelic medicines from July 2023, psychotherapeutic treatment using these medicines has become available in the private sector, making it possible for general practitioners (GPs) to refer their patients with treatment-resistant depression or post-traumatic stress disorder (PTSD). Several other psychedelic...
Rodent studies have shown that psychedelic drugs can enhance fear extinction. However, investigations to date have relied on normative aversive conditioning procedures, which limit their relevance to trauma-related memories, as these tend to be overgeneralized and resistant to extinction. Fear extinction depends on activity and plasticity within the infralimbic (IL) region of the medial...
Psychedelic- and substance-assisted therapies, including MDMA, psilocybin, and ketamine, are gaining attention for conditions such as PTSD and depression, yet their development and implementation remain largely concentrated in high-income settings. This graphical abstract summarizes the central argument of the commentary: while these interventions may hold relevance for global mental health,...
The neurotic disorders (e.g., depression, dysthymia, generalized anxiety disorder, panic disorder, agoraphobia, social anxiety, post-traumatic stress disorder, and obsessive-compulsive disorder) are costly and difficult to treat. Diagnosis is based on symptoms not biological causes. Here, we summarize New Zealand-based work developing EEG biomarkers and novel treatments. Working at the...
Introduction: Comorbid conditions such as major depressive disorder, anxiety disorders, and posttraumatic stress disorder are common among Veterans, and the presence of multiple conditions requires innovative treatment approaches. The Newly Institute in Calgary, Alberta, Canada, has introduced a novel intervention combining sublingual ketamine therapy with a medically managed transdiagnostic...
Classic psychedelics, such as psilocybin, lysergic acid diethylamide (LSD), and N,N-dimethyltryptamine (DMT), have emerged as potent modulators of neuroplasticity and metaplasticity in the adult brain, offering novel therapeutic strategies for neuropsychiatric disorders. Recent findings reveal that beyond their transient psychotropic effects, these compounds activate serotonin 5-HT2A receptors...