Abstract Psilocybin, a naturally occurring psychedelic compound found in certain fungi has long been used by Indigenous cultures within ritual and ceremony for healing and spiritual purposes (Spiers et al., 2024). While emerging evidence points to psychedelic agents being novel avenues for the treatment of substance use disorders, the predominantly Western medical models of psychedelic-assisted...
AbstractBackgroundThere is a need to systemically diversify psychedelic clinical trials, considering the growing interest in in the therapeutic potential of psychedelics within Black, Indigenous, and Peoples of Color (BIPOC) and queer communities. Doing so contributes to a more inclusive foundation of evidence-based research and addresses ethical considerations surrounding anticipated demand...
The interplay between psychedelics, such as psilocybin, lysergic acid diethylamide (LSD) and dimethyltryptamine (DMT), and sleep is an emerging area, but their impact on sleep remains relatively underexplored. This viewpoint provides a perspective on how psychedelics may alter sleep phases, dreaming, and their potential therapeutic applications for sleep disorders.
Introduction The aesthetic qualities of psychedelic experiences have long been documented, but their specific contribution to therapeutic outcomes remains understudied. Aesthetic experiences may facilitate emotional breakthroughs and cognitive shifts, potentially playing a crucial role in the lasting psychological benefits observed following psychedelic use. Methods This cross-sectional study...
Abstract The fictional story, Cornutopia , by British-Nigerian author Irenosen Okojie, offers a critical outsider's perspective on the enthusiasm surrounding psychedelic research, notably from outside the small world of psychedelic research. The protagonist, Amel Dyani, a young Black woman, participates in a psychedelic clinical trial but has a negative experience. This article aims to analyse...
This viewpoint explores the therapeutic potential of psychedelics in treating neuropsychiatric disorders, particularly through the modulation of brain entropy and the experience of ego dissolution. Psychedelics disrupt rigid neural patterns, facilitating enhanced connectivity and fostering profound emotional breakthroughs that may alleviate symptoms of disorders like depression, anxiety, PTSD,...
Despite large improvements in depressive symptoms in the psilocybin group, psilocybin therapy had only a minor effect on brain responsiveness to emotional stimuli. These results are consistent with prior findings that the antidepressant action of SSRIs is often accompanied by a reduction in emotional responsiveness, but this effect may not occur in psychedelic therapy.
Future HumanitiesMay 1, 2025Ernesto Grillo Rabello, Fabio Hebert da Silva
Psychedelic‐assisted therapies can be intertwined with the forces of neoliberal rationality, reductionist psychiatry, biomedical psychopharmacology, individualized models of subjectivity and fascism. Through a genealogical and critical review, this study seeks to demonstrate how the ongoing ‘psychedelic renaissance’ and its current medicalization of psychedelics may reinforce historical...
May 1, 2025Eve E. Keighley, Dalia A Bedewy, Eid Abo Hamza et al.1 citation
preprint
Given the recent resurgence of using psychedelic drugs to treat substance misuse (SM), reviewing the latest information on their current status is essential. Substance use disorders (SUD) are psychiatric conditions that comprise the repetitive use of illicit substances, despite the harmful and damaging ramifications. Current treatment options for SUD are limited and have displayed low...
Cephalalgia ReportsMay 1, 2025Jonathan A. Leighton, Chieh Grace Lau, Aisha Savdo et al.2 citations
Background Cluster headache is an excruciating condition for which standard treatments are usually insufficient. Evidence has accumulated that serotonergic psychedelic indoleamines including psilocybin and LSD can be effective in preventing attacks. Methods In this case series, nine patients with episodic and chronic cluster headache that didn’t respond to conventional treatments were treated...