Serotonergic psychedelic drugs are under investigation as therapies for various psychiatric disorders, including major depression. Although serotonergic psychedelic drugs are 5-HT2A receptor agonists, some such agonists are not psychedelic, potentially due to differences in 5-HT2A receptor ligand bias or signalling efficacy. Here, we investigated 5-HT2A receptor signalling properties of...
Preprints.orgJune 19, 2025Danial Daroui, Andrea Mastrostefano, Flavio Davini et al.1 citation
preprint
Background: Alcohol Use Disorder (AUD) is a chronic pathological condition with significant burdens throughout the world. Despite the effectiveness of the current pharmacological treatments, the ongoing issues with AUD and the high relapse rates necessitate the exploration of innovative therapies, including the use of psychedelic drugs, which have shown promising initial results. The purpose of...
CellsJune 19, 2025Júlia Jarne-Ferrer, Mercè Pallàs, Christian Griñán-Ferré et al.2 citations
Alzheimer's disease (AD) is a chronic and complex neurodegenerative disorder characterized by progressive cognitive decline, memory loss, and irreversible impairment of brain functions. The etiology of AD is multifactorial, involving a complex interplay of genetic, environmental, and physiological factors, including the aggregation of amyloid-β (Aβ) and oxidative stress (OS). The role of OS in...
This chapter describes the traditions, training, alterations of consciousness, healing ritual, and ethnomedical ideologies of Cannabis sativa, which is the oldest, most widely used, yet least considered plant teacher of the psychedelic renaissance. After briefly summarizing the recent literature about the deeply intertwined histories of Cannabis sativa and its intimate relationship with human...
The psychoactive brew Ayahuasca has a central role in the traditional medicines of the indigenous people of the Amazon basin and in recent decades has generated significant research interest among the academic community along with the revival of psychedelic medicine. The therapeutic community Takiwasi, located in Peru, leads this movement in its dedication to treatment of substance use...
Current regulation frameworks for medicines struggle to address the combination of pharmacological and psychotherapeutic elements in psychedelic therapy. We propose a more appropriate and advantageous approach may be to regulate psychedelic drugs as therapeutic tools or adjuncts to psychotherapy, rather than as treatments for specific mental disorders. Drawing parallels with anesthetics, which...
This chapter describes a psychedelic healing protocol developed by Bénédicte Mannix for treating childhood trauma, explaining its therapeutic approaches and the philosophical and psychological traditions that inform her healing practices. The motivation for the development of this protocol has been to harness the power of psilocybin to heal human minds, bodies, and souls from psychological...
This chapter details the therapy protocols involving ibogaine utilized at The Mission Within (https://missionwithin.org) in Baja California, Mexico, as described by its founder and research director, Dr. Martin Polanco, along with psychedelic preparation/integration counselor and therapeutic facilitator, Dr. Mia Black. The chapter describes: Their personal development as ibogaine therapists and...
Currently, the most actively investigated rapidly acting antidepressants, anxiolytics and/or anti PTSD agents, include psychedelics e.g. psilocybin, LSD, N , N ‐dimethyltryptamine, ayahuasca; non‐hallucinogenic entactogens, e.g. MDMA; psychoplastogens which rapidly promote neuroplasticity, e.g. ibogaine, ketamine and esketamine; and other atypicals e.g. dextromorphan/bupropion, esmethadone....
Abstract Psychedelic-assisted groups (PAGs) indicate promise with clients that do not respond to traditional talk therapy. While encouraging, in the U.S., societal perceptions of psychedelics and concern of practicing outside one’s scope may cause practitioners to hesitate. To illustrate the potential effectiveness of PAGs, this article has three parts. First is a historical overview of...