Stroke remains a leading cause of death and long-term disability and stroke patients have only limited treatment options.Recent preclinical evidence suggests that psychedelics such as psilocybin may confer cerebroprotection by engaging serotonin (5-HT) receptor pathways, yet their cellular targets and translational potential remain poorly understood.Here, we propose to systematically evaluate...
Abstract First-hand experience with psychedelics may help clinicians develop skills and knowledge needed to work with the profound changes to conscious awareness occasioned by psychedelics. However, the topic remains contentious and underexplored. In this world-first study, we investigated the utility of psilocybin experiential therapist training in a sample of 14 mental healthcare...
DELOS Desarrollo Local SostenibleNovember 12, 2025Maria Eduarda Mesquita Gonsalves, Beatriz Moreira Brazil, Maurício Cupello Peixoto
O Transtorno de Estresse Pós-Traumático (TEPT) é uma condição mental que pode surgir após experiências traumáticas, afetando a qualidade de vida dos indivíduos. O tratamento convencional envolve psicoterapia e farmacoterapia, contudo, nem sempre apresenta resultados satisfatórios. Nesse cenário, a psicoterapia assistida por 3,4-metilenodioximetanfetamina (MDMA) tem emergido como alternativa...
This Viewpoint discusses how to fill policy gaps surrounding the use of psychedelics to treat mental health and substance use conditions, should they be approved by the US Food and Drug Administration.
Psychedelics are being investigated as therapies for major depression and other mood disorders, but the “tripping” experience remains poorly understood. This paper argues that the epistemic dimensions of psychedelic experience should be considered more carefully, both to characterize better the psychedelic state and to develop and explain therapeutic approaches. I propose a tripartite framework...
Metabolic EngineeringNovember 5, 2025Cui Guo, Nguyen N T Luu, Maryem M Adwer et al.5 citations
Psychedelic-assisted therapy is emerging as a highly promising approach for treating depression, with psilocybin, a psychoactive compound in magic mushrooms, gaining the most recognition for its efficacy in treating post-traumatic stress disorder and treatment-resistant depression. However, its low natural abundance makes extraction costly, necessitating alternative production methods. While...
Religious and spiritual (R/S) practices and experiences invoke measurable neurocognitive processes that enhance resilience and recovery from affective disorders. Converging evidence from functional neuroanatomy and network studies demonstrate R/S practices recruit brain networks that regulate self-referential processing, salience attribution, executive control, reward, and social bonding....
The past two decades have seen the reemergence of research investigating the therapeutic potential of psychedelic drugs across neuropsychiatric illnesses. One condition, alcohol use disorder (AUD), is of relevance given the broad public health implications and both limited effectiveness and attrition associated with currently available treatments. While emerging research has suggested that the...
Background: Posttraumatic stress disorder (PTSD) is associated with maladaptive memory reconsolidation and overgeneralized fear responses. EMDR therapy promotes trauma reprocessing by activating the brain's intrinsic memory reconsolidation mechanism, facilitating memory updating, and abandoning outdated emotional schemas. Ketamine may also facilitate adaptive updating of traumatic memory due to...
ABSTRACT In Expansion and Regression in Oceanic Experience, Peoples and Rundel examine “what happens from a psychoanalytic perspective when a patient engages in psychedelic-assisted therapy.” In an elegant paper that has both a clinical and theoretical focus, they discuss what Romain Rolland described metaphorically as the “oceanic feeling.” They believe such feelings can have transformative...