Psychiatric Clinics of North America
June 1, 2012
Stephen Ross
54 citations
Only time will tell if serotonergic hallucinogen-assisted psychotherapy treatment paradigms for SUDs will prove to be safe and effective in double-blind, placebo-controlled clinical trials. If they are, they would truly constitute a novel psychopharmacologic-psychosocial treatment paradigm to treat addictive disorders, although the risk of adverse psychological events would have to be...
Psychopharmacology
December 1, 2011
Roland R. Griffiths, Matthew W Johnson, William A Richards et al.
938 citations
This dose-effect study extends previous observations showing that psilocybin can occasion mystical-type experiences having persisting positive effects on attitudes, mood, and behavior. This double-blind study evaluated psilocybin (0, 5, 10, 20, 30 mg/70 kg, p.o.) administered under supportive conditions. Participants were 18 adults (17 hallucinogen-naïve). Five 8-h sessions were conducted...
The Canadian Journal of Psychiatry
June 1, 2005
Erika Dyck
88 citations
In the popular mind, d-lysergic acid diethylamide (LSD) research in psychiatry has long been associated with the CIA-funded experiments conducted by Ewen Cameron at the Allen Memorial Institute in Montreal, Quebec. Despite this reputation, a host of medical researchers in the post World War II era explored LSD for its potential therapeutic value. Some of the most widespread trials in the...
Pharmacology & Therapeutics
May 1, 2004
Dennis J. Mckenna
299 citations
Ayahuasca is a hallucinogenic beverage that is prominent in the ethnomedicine and shamanism of indigenous Amazonian tribes. Its unique pharmacology depends on the oral activity of the hallucinogen, N,N-dimethyltryptamine (DMT), which results from inhibition of monoamine oxidase (MAO) by beta-carboline alkaloids. MAO is the enzyme that normally degrades DMT in the liver and gut. Ayahuasca has...
Journal of Substance Abuse Treatment
December 1, 2002
Evgeny Krupitsky, Andrey Burakov, Tatyana N. Romanova et al.
240 citations
Seventy detoxified heroin-addicted patients were randomly assigned to one of two groups receiving ketamine psychotherapy (KPT) involving two different doses of ketamine. The patients of the experimental group received existentially oriented psychotherapy in combination with a hallucinogenic ("psychedelic") dose of ketamine (2.0 mg/kg im). The patients of the control group received the same...
Medical History
April 1, 2002
Stephen Snelders, Charles D. Kaplan
27 citations
The use of the word "hallucinogens" to classify LSD and other drugs is common-sensical, vague and sometimes confusing. The classification scheme of Jean Delay, first suggested in 1959, is more clinically precise. In this scheme hallucinogens are classified as psychodysleptics (psycho-dysleptiques) because of their characteristic psychological effects: disturbance of mental activity and the...
Journal of Psychoactive Drugs
2002
Marlene Dobkin De Rios, Charles S. Grob, John R. Baker
58 citations
This article examines drug substitution with regard to hallucinogens (ayahuasca, ibogaine, peyote and LSD) set within the concept of redemption. The model examines both religious and secular approaches to the contemporary use of hallucinogens in drug substitution, both by scientists and in religious settings worldwide. The redemptive model posits that the proper use of one psychoactive...
Journal of Psychoactive Drugs
December 1, 1998
R Doblin
29 citations
This study is a long-term follow-up to the Concord Prison Experiment, one of the best-known studies in the psychedelic psychotherapy literature. The Concord Prison Experiment was conducted from 1961 to 1963 by a team of researchers at Harvard University under the direction of Timothy Leary. The original study involved the administration of psilocybin-assisted group psychotherapy to 32 prisoners...
Journal of Psychoactive Drugs
1998
M Mangini
107 citations
Following Albert Hofmann's discovery of LSD's psychoactive properties in 1943, and previous to their scheduling as controlled substances, the psychedelic drugs were widely studied--six international conferences and hundreds of papers discussed their potential therapeutic usefulness. The observation that the frightening experience of delirium tremens sometimes led alcoholics to moderate their...
Journal of Religion and Health
December 1, 1985
C M Bache
18 citations
This essay offers a reassessment of Teresa's severe seizures which were such a characteristic feature of her mysticism. The diagnosis of hysteria is no longer viable, at the very least given its abandonment by clinicians. An alternative analysis is developed by phenomenologically comparing Teresa's seizures to parallel experiences of subjects in LSD-assisted psychotherapy. Using Stanislav...