December 10, 2025
Judith Hooper, Sarah Williams, Raeghan L. Mueller et al.
2 citations
preprint
As psychedelic use increases, understanding how demographic and behavioral factors influence the effects of psychedelics is essential for both research and public health. This cross-sectional retrospective study examined 365 people who currently use psilocybin, analyzing differences in acute experiences, psychological outcomes, and substance co-use patterns. Participants were categorized into...
JAMA Psychiatry
November 5, 2025
Kent E. Hutchison, Judith Hooper, Hollis C Karoly
10 citations
Importance Psilocybin use has surged in the US following decriminalization efforts and promising clinical trial results. Mirroring early cannabis legalization, public access and enthusiasm are outpacing regulatory oversight and scientific understanding, posing potential risks to public health. Objective To review emerging evidence on the public health implications of unregulated psilocybin...
Annals of Internal Medicine
October 1, 2025
Thanitsara Rittiphairoj, Louis Leslie, Jean-Pierre Oberste et al.
12 citations
Rapid changes in the legalized cannabis market have led to the predominance of high-concentration delta-9-tetrahydrocannabinol (THC) cannabis products. To systematically review associations of high-concentration THC cannabis products with mental health outcomes. Ovid MEDLINE through May 2025; EMBASE, Allied and Complementary Medicine Database, Cochrane Library, Database of Abstracts of Reviews...
Frontiers in Psychology
September 15, 2025
Judith Hooper, Jarrod M. Ellingson, Kent E. Hutchison
2 citations
Introduction Aesthetic experiences under psychedelics are often described as vivid, emotionally powerful, and meaningful, yet they remain under-measured in psychometric research. This study aimed to refine and validate the Psychedelic Aesthetic Experience Questionnaire (PAEQ), a novel instrument designed to assess the aesthetic dimensions of acute psychedelic experiences. Methods A total of 365...
Neuropsychologia
July 26, 2025
Jake Hooper, Devon Stoliker, Kyle Wolfe et al.
1 citation
Neuroaesthetics is a subdiscipline within cognitive neuroscience which describes the biological mechanisms of aesthetic experiences. These experiences encompass perceptions and evaluations of natural objects, artwork, and environments that are ubiquitous in daily life. Empirical research demonstrates that aesthetic experiences arise from an interplay of sensory, affective, and semantic...
Frontiers in Psychology
May 15, 2025
Jake Hooper, Emily L Gyongyosi, Kent E. Hutchison et al.
5 citations
Introduction The aesthetic qualities of psychedelic experiences have long been documented, but their specific contribution to therapeutic outcomes remains understudied. Aesthetic experiences may facilitate emotional breakthroughs and cognitive shifts, potentially playing a crucial role in the lasting psychological benefits observed following psychedelic use. Methods This cross-sectional study...
Cannabis and Cannabinoid Research
February 1, 2025
Margy Y. Chen, Emily B Kramer, Laurel P Gibson et al.
Objective: Cannabis has been touted for a host of pharmacological and therapeutic effects and users commonly report reduced symptoms of physical and mental health conditions, including anxiety, depression, and chronic pain. While there is existing empirical evidence supporting these effects of cannabis use, little is known about the extent to which these effects result from pharmacological...
PsyArXiv
October 18, 2024
Jake Hooper, Emily L Gyongyosi, Kent E. Hutchison et al.
preprint
Objective: The aesthetic qualities of psychedelic experiences have long been documented, but their specific contribution to therapeutic outcomes remains unexplored. This study investigates the role of psychedelic-induced aesthetic experiences in predicting positive psychological outcomes. Methods: Using a cross-sectional naturalistic survey, participants who had recently used classic...
Cannabis and Cannabinoid Research
February 1, 2024
Laurel P Gibson, Raeghan L. Mueller, Evan A Winiger et al.
Background: The popularity of edible cannabis products continues to grow in states with legal cannabis access, but few studies have investigated the acute effects of these commercially available products. The present study sought to explore the effects of three commercially available edible products with different levels of delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD). Methods: A...
Cannabis and Cannabinoid Research
January 22, 2024
L. Bidwell, Renée Martin-Willett, Carillon J. Skrzynski et al.
Objective: Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD) have varying pharmacological actions with differential effects on acute and extended affective states, incuding anxiety. We aimed to study these effects on anxiety in legal market forms of cannabis. Method: This study makes use of a nonequivalent control group quasiexperimental design. Forty-two participants with anxiety symptions...
Addiction Biology
2022
Laurel P Gibson, Hollis C Karoly, Jarrod M. Ellingson et al.
Using a federally compatible, naturalistic at-home administration procedure, the present study examined the acute effects of three cannabis flower chemovars with different tetrahydrocannabinol (THC) to cannabidiol (CBD) ratios, in order to test whether chemovars with a higher CBD content produce different effects. Participants were randomly assigned to ad libitum administration of one of three...