Medical ScienceJuly 30, 2025Barbara Anna Zapalska, Antonina Teresa Witkowska, Anna Cukrowska et al.
Depression, a common mental disorder, affects people at different stages of life.Classic antidepressant treatment is generally effective, however, it is prolonged.Nonetheless, numerous patients who undergo various classic antidepressant therapies still suffer from depression.Therefore, the search for novel medications is essential.In this review, we explore the therapeutic potential of...
Inner healing intelligence (IHI) is a foundational orienting concept in the psychedelic-assisted therapy (PAT) field that refers to the innate tendency of living beings to move towards healing. In this paper, we introduce an expanded articulation of IHI, drawing largely on vitalism and Indigenous philosophy from the Americas. We conceptualize IHI as the innate capacity of an individual to move...
Psychedelic-assisted psychotherapy emphasizes the transformative power of mystical-type peak experiences. Stroboscopic ganzfeld (ganzflicker) stimulation offers a non-pharmacological analogue to psychedelic drugs. This exploratory self-experimentation study investigated whether anxiety-neutralizing techniques (eye movements, square breathing) enhance the brightness of visual hallucinations...
Abstract Background and Aims Psilocybin has emerged as a potential treatment for alcohol use disorder (AUD), but early efficacy data are inconsistent. Depression following alcohol detoxification significantly increases the risk of relapse. This pilot study aimed to evaluate the feasibility, acceptability, and preliminary efficacy of psilocybin‐assisted psychotherapy for patients with comorbid...
Psilocybin's efficacy as a treatment for treatment-resistant depression (TRD) has led to a wave of new legislation permitting its usage in medical settings. Older adults are affected disproportionately by TRD and may be especially good candidates for this promising treatment. However, due to the drug's past (and present) illicit status and exposure to historic antidrug messaging, older...
Introduction: Psychedelics are emerging as potential treatments for neuropsychiatric conditions, with evidence suggesting a single administration can lead to enduring behavioural changes. While the underlying putative mechanism(s) remain unclear, there is evidence supporting altered learning as a key candidate. Aim: This systematic review examined studies assessing the effects of psychedelics...
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A revolutionary change in contemporary therapeutic paradigms may be seen in the renewed interest in psychedelic plant remedies. Psychedelic plants like psilocybe mushrooms, ayahuasca, iboga, and salvia divinorum, which have long been valued for their spiritual and therapeutic qualities in a variety of cultures, are now the subject of intense scientific research. According to recent clinical...
Psychedelic clinical study environments are frequently visually manipulated, such as art; however, there has been little study of how the art selected for display impacts individual responses to the overall setting. To examine how individual self-identities shape perceptions of art used in a clinical psychedelic dosing environment, this study used a community-engaged mixed-methods approach....
The influence of ovarian hormone fluctuations on neurochemistry, cognition, and psychological responses remains insufficiently examined in current psychedelic research and clinical protocols. Traditional practices and case studies underscore the importance of accounting for these factors in investigations of psychedelic effects. This opinion paper explores the critical intersections between...