While growing evidence suggests that psychedelic-assisted therapy may have antidepressant effects in certain populations, little is known about the effects of psychedelic use on depressive symptoms in non-clinical, naturalistic settings. This observational cohort study included a large sample of US residents (18-50 years old) and longitudinally evaluated the relationships between naturalistic...
Psychedelics are known to elicit intense and meaningful subjective experiences. These subjective experiences are supposed to play a major role in psychedelic-assisted psychotherapy. However, not much attention has been paid to the role played by emotions in these experiences. In this paper, we argue that typical psychedelic-induced experiences share many phenomenological features with two...
Psychedelic-assisted therapies and ketamine are two modalities gaining attention in psychiatry for treating conditions such as depression, PTSD, and substance use disorders. However, perceptions of these treatments vary globally. This study explores the familiarity, attitudes, and perceptions of Jordanian physicians and medical students toward psychedelic substances, addressing a gap in Middle...
The phenomenology of psychedelic experiences has been a long-standing point of interest to researchers. However, internal experience has been relatively relegated, with much work done on the clinical outcomes of psychedelic therapies. Our reflexive thematic analysis revealed that structurally, people on fora write about their experiences sequentially, considering factors prior to (preparatory),...
Abstract Background : Military veterans are at risk of various mental health conditions, with profound implications for post‐deployment quality of life. Current treatment options encounter high dropout rates and non‐responsiveness, and overlook the importance of community building in veterans’ holistic recovery. Preliminary research suggests psychedelics offer therapeutic benefits for...
Both psychotherapeutic interventions and pharmacological agents have demonstrated limited efficacy in the treatment of personality disorders (PDs). Emerging evidence suggests that psychedelic therapy, already showing promise in treating various psychiatric conditions commonly comorbid with PDs, may exert therapeutic effects by promoting adaptive changes in personality. Thus, psychedelic therapy...
Psychedelic treatments are emerging as promising interventions for many mental health conditions. These interventions are not offered in a standardized fashion across studies and between different healthcare centers. Beyond differences in substances and doses, there is also a great heterogeneity in the interventions provided by therapists. The current review offers a summary of important...
Aracê.June 27, 2025Gabriel Bispo Do Carmo, Janaína Da Silva Feitoza Palácio, Maria Cristina de Andrade et al.
Treatment-resistant depression (TRD) represents one of the greatest clinical challenges in contemporary psychiatry, significantly affecting patients' functionality and quality of life. Given the limitations of conventional therapies, psilocybin, a psychedelic substance derived from fungi of the Psilocybe genus, has gained prominence as a promising therapeutic alternative. This study aimed to...
Objective: This study investigates the psychological mechanisms through which 5-methoxy-N, N-dimethyltryptamine (5-MeO-DMT) influences mental health outcomes, with a focus on fear confrontation, emotional release, and intergenerational trauma. Design: A qualitative methodology was employed, combining grounded theory and qualitative comparative analysis (QCA). Fourteen individuals who had...
Psychedelics are increasingly used in the general population, yet they are associated with increased risk of psychosis in a minority of users that can experience psychedelic-induced psychosis (<1 % in controlled trial settings). In contrast, the evidence regarding the treatment of psychedelics-induced psychosis remains to date scarce. We conducted a PRISMA 2020-compliant systematic review...