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Emergency Medicine News December 1, 2003 Leon Gussow
A 25-year-old man was brought to the emergency department from a late-night dance club. A friend reported that the patient commonly used designer drugs that he purchased over the Internet. While at the club, he started to vomit and experience visual hallucinations. He had no previous medical history and took no prescription medications. On searching the patient's clothing, medical staff found...
Psychopharmacology December 1, 2002 Jordi Riba, Antoni Rodrı́guez-fornells, Manel J. Barbanoj 71 citations
RationaleAyahuasca, a South American psychotropic plant tea, combines the psychedelic agent and 5-HT(2A/2C) agonist N, N-dimethyltryptamine (DMT) with beta-carboline alkaloids showing monoamine oxidase-inhibiting properties. Current human research with psychedelics and entactogens has explored the possibility that drugs displaying agonist activity at the 5-HT(2A/2C) sites temporally disrupt...
Journal of Psychoactive Drugs September 1, 2002 Jos Ten Berge 13 citations
Historically, states of intoxication--like dreams and madness--are seen in either one of two opposed ways. The intoxicated are either "possessed" or "under the influence" of an external agency, or revealing hidden feelings or truths (in vino veritas). Along the same lines, artists who worked during LSD, mescalin or psilocybin intoxication often refer to feelings of either being "possessed" or...
The Canadian Journal of Psychiatry August 1, 2002 Samantha R. Gross, Sean P. Barrett, John S. Shestowsky et al. 97 citations
Objective: This study investigates the drug consumption patterns of a sample of rave attendees in the city of Montreal, Quebec, and seeks to identify the prevalence of 3,4-methylendioxymethamphetamine (MDMA) and other drug use in this population. Method: We administered a self-report questionnaire to 210 respondents. For various licit and illicit substances, participants reported their age of...
Neuropsychopharmacology May 1, 2002 C Nichols 165 citations
Hallucinogenic drugs such as lysergic acid diethylamide (LSD) have profound effects on humans including hallucinations and detachment from reality. These remarkable behavioral effects have many similarities to the debilitating symptoms of neuropsychiatric disorders such as schizophrenia. The effects of hallucinogens are thought to be mediated by serotonin receptor activation; however, how these...
Therapeutic Drug Monitoring April 1, 2002 Manfred R. Moeller, Thomas Kræmer 98 citations
Driving under the influence of drugs is an issue of growing concern in the industrialized countries as a risk and a cause for road accidents. In forensic toxicology, the increasing number of samples for determination of drugs in blood is mainly due to zero-tolerance laws in several countries and well-trained police officers who can better recognize drivers under the influence of drugs of abuse....
Neural Computation March 1, 2002 Paul C. Bressloff, Jack D. Cowan, Martin Golubitsky et al. 292 citations
Many observers see geometric visual hallucinations after taking hallucinogens such as LSD, cannabis, mescaline or psilocybin; on viewing bright flickering lights; on waking up or falling asleep; in “near-death” experiences; and in many other syndromes. Klüver organized the images into four groups called form constants: (I) tunnels and funnels, (II) spirals, (III) lattices, including honeycombs...
Dialogues in Clinical Neuroscience December 31, 2001 Franz X. Vollenweider 127 citations
This review focuses on recent brain imaging and behavioral studies of sensory gating functions, which assess similarities between the effects of classic hallucinogens (eg, psilocybin), dissociative anesthetics (eg, ketamine), and entactogens (eg, 3,4-methylenedioxymethamphetamine [MDMA]) in humans. Serotonergic hallucinogens and psychotomimetic anesthetics produce overlapping psychotic...
Addiction July 1, 2001 Sarah Riley, Charlotte James, Danielle Gregory et al. 172 citations
Aims . To describe the patterns of drug use at dance (rave) events in terms of prevalence, frequency, type of drugs used, patterns of use, access and risk‐associated behaviours. Design . Self‐selecting participant‐completed survey. Setting . Three dance events in Edinburgh, Scotland, UK. Participants . One hundred and twenty‐two drug users (57% males, 43% females), 90% of whom were in...
Psychopharmacology February 22, 2001 Jordi Riba, Antoni Rodrı́guez-fornells, Gloria Urbano et al. 302 citations
RationaleAyahuasca is a South American psychoactive beverage that contains the naturally occurring psychedelic agent N,N-dimethyltryptamine (DMT). This "tea" has been used for centuries in religious and medicinal contexts in the rain forest areas of South America and is presently gaining the attention of psychedelic users in North America and Europe.ObjectivesIn the present study, the...