Pharmacopsychiatry
July 1, 1998
K.-A. Kovar
32 citations
Amphetamines, tryptamines, phencyclidines, tetrahydrocannabinol and substances of the ecstasy group are characterized as stimulants, hallucinogens and entactogens. The various effects of each group and their mode of action in different transmitter systems are described. 28 new compounds of the amphetamine and tryptamine series has been calculated, which exceed the hallucinogenic effects of...
Pharmacopsychiatry
July 1, 1998
Euphrosyne Gouzoulis‐mayfrank, Frank Schneider, J. Friedrich et al.
16 citations
Human experimental research with hallucinogenic drugs is potentially able to identify linking variables between the psycho(patho)logical conditions and neurobiological alterations involved in both pharmacologically induced and naturally occurring acute psychotic states. A number of methodological aspects should be considered when planning modern experimental studies with hallucinogenic drugs....
Pharmacopsychiatry
July 1, 1998
Franz X. Vollenweider
131 citations
Recent research into the pharmacological mechanism of hallucinogens (LSD, psilocybin) and dissociative anesthetics (PCP, ketamine) suggest that multiple neurotransmitter systems are involved in drug-induced and possibly also in naturally occurring psychoses. Specifically, animal models suggest that a dysbalance between serotonin, glutamate, and dopamine in the limbic cortico-striato-thalamic...
Drug and Alcohol Dependence
June 1, 1998
Gerard J. Marek, George K. Aghajanian
39 citations
The psychedelic hallucinogens are comprised of three different groups of compounds according to Ž . Ž . their chemical structure Fig. 1 : 1 the ergolines Ž which contain an indole moiety e.g. lysergic acid . Ž . diethylamide, LSD ; 2 simple indoleamine hallucinoŽ gens e.g. N,N-dimethyltryptamine, DMT and psilocy. bin which share an indoleamine structure with the Ž endogenous neurotransmitter...
Journal of Analytical Toxicology
1998
Olof Beck, Anders Helander, Christine Karlson-Stiber et al.
58 citations
The use of mushrooms containing the hallucinogenic substance psilocybin for intentional intoxication is relatively common. Occasionally, this results in adverse reactions with typical tachycardia that is not evidently caused by psilocybin. This study demonstrates the presence of phenylethylamine in the species Psilocybe semilanceata using gas chromatography-mass spectrometry and shows that the...
Isis
March 1, 1997
Steven J. Novak
68 citations
In 1962 Sidney Cohen presented the medical community with its first warning about the dangers of the drug LSD. LSD had arrived in the United States in 1949 and was originally perceived as a psychotomimetic capable of producing a model psychosis. But in the mid 1950s intellectuals in Southern California redefined LSD as a psychedelic capable of producing mystical enlightenment. Though LSD was an...
The Journal of Nervous and Mental Disease
February 1, 1996
Charles S. Grob, Dennis J. Mckenna, James C. Callaway et al.
333 citations
A multinational, collaborative, biomedical investigation of the effects of hoasca (ayahuasca), a potent concoction of plant hallucinogens, was conducted in the Brazilian Amazon during the summer of 1993. This report describes the psychological assessment of 15 long-term members of a syncretic church that utilizes hoasca as a legal, psychoactive sacrament as well as 15 matched controls with no...
Nordic Journal of Psychiatry
1996
Jørgen Due Madsen, Asle Hoffart
7 citations
Psychotherapeutic treatment with hallucinogens, usually called psycholytic treatment, was used at Modum Bads Nervesanatorium (MBN) on inpatients from 1961 to 1976. The hallucinogens used were LSD, psilocybin, and CZ 74. The indications and the treatment procedure at MBN are described. From 1961 to 1976, 379 patients received 2205 psycholytic treatments, mostly with LSD. From 1970 to 1976, only...
Behavioural Brain Research
December 1, 1995
Rick J. Strassman
257 citations
We generated dose-response data for the endogenous and ultra-short-acting hallucinogen, N,N-dimethyltryptamine (DMT), in a cohort of experienced hallucinogen users, measuring multiple biological and psychological outcome measures. Subjective responses were quantified with a new rating scale, the HRS, which provided better resolution of dose effects than did the biological variables. A tolerance...
Behavioural Pharmacology
April 1, 1995
Lisa E Baker, Jonathan M. Broadbent, E. K. Michael et al.
52 citations
The discriminative stimulus effects of the stereoisomers of 3,4-methylenedioxymethamphetamine (MDMA) were studied in rats trained to discriminate 1.25mg/kg of (+)-MDMA or 3.5mg/kg of (-)-MDMA from saline, in a two lever, water-reinforced, drug discrimination situation. The isomers of MDMA and 3,4-methylenedioxyamphetamine (MDA) substituted completely for both training drugs. The stimulants...