Clinical Toxicology
July 1, 2009
Kristian Björnstad, Peter Hultén, Olof Beck et al.
35 citations
Problems associated with the increasing abuse of plant-derived psychoactive substances have recently attracted attention. This study involved bioanalytical and clinical examinations of intoxication cases suspected to be linked to such plant materials. Urine samples were collected at emergency wards in Sweden from patients who either admitted or were suspected of ingestion of psychoactive plant...
Therapeutische Umschau
April 28, 2009
R Flammer, Katharina Schenk-Jäger
3 citations
Most mushroom intoxications become evident within 12 hours with vomiting and diarrhea. They can be divided into incidents with a short latency (less than four hours) and incidents with a long latency (longer than four hours). As a rule of thumb amatoxin poisonings must be considered in case of symptoms appearing with a long latency (8-12-18 h), especially after consumption of non-controlled...
Current Medicinal Chemistry
March 1, 2009
Javier González-Maeso, Stuart C. Sealfon
74 citations
Seven transmembrane domain receptors, also termed G protein-coupled receptors (GPCRs), represent the most common molecular target for therapeutic drugs. The generally accepted pharmacological model for GPCR activation is the ternary complex model, in which GPCRs exist in a dynamic equilibrium between the active and inactive conformational states. However, the demonstration that different...
Oxidative Medicine and Cellular Longevity
2009
Peter Kovacic, Ratnasamy Somanathan
34 citations
A unifying mechanism for abused drugs has been proposed previously from the standpoint of electron transfer. Mescaline can be accommodated within the theoretical framework based on redox cycling by the catechol metabolite with its quinone counterpart. Electron transfer may play a role in electrical effects involving the nervous system in the brain. This approach is in accord with structure...
Inflammation and Regeneration
2009
Yoshihiro Matsushima, Fumio Eguchi, Tadahiro Kikukawa et al.
29 citations
Humans have used psychoactive mushrooms for medical, recreational, religious and ritual purposes since pre-history. Previous studies have clarified that psychoactive mushrooms produce psychoactive agents such as psilocybin, psilocin, ibotenic acid, and muscimol. However, the status of psychoactive mushrooms in most countries as illegal hallucinogens has prevented full investigation of their...
Contemporary Justice Review
November 18, 2008
Adam Jacobs
3 citations
Recently the use of hallucinogens in therapy has resurfaced in clinical research. Decades after dismissing Timothy Leary for his experiments, Harvard approved clinical trials using psilocybin (mushrooms) in therapy with terminally ill patients. This article re‐evaluates the research on LSD as a therapeutic element. A re‐assessment of the earlier legal research on hallucinogenic therapy reveals...
The American Journal of Emergency Medicine
October 1, 2008
Ryan L McClintock, David J Watts, Scott Melanson
A 28-year-old man with a history of drug and alcohol abuse presented multiple times to the hospital over 2 months with an elusive constellation of symptoms, resolving spontaneously in each instance. This patient required a high level of care for management and stabilization, including 3 emergency department visits, 2 medical floor admissions, and 1 intensive care unit admission. In both the...
TIPS - Trends in Pharmacological Sciences
August 1, 2008
Mark A. Geyer, Franz X. Vollenweider
435 citations
The history of serotonin research is closely related to the study of hallucinogenic drugs that function as agonists at serotonin-2A receptors. The fundamental idea that psychotic states seen in psychiatric disorders such as schizophrenia might be attributable, in part, to abnormalities in serotonergic systems began with the almost simultaneous discovery of lysergic acid diethylamide (LSD),...
Fortschritte der Neurologie · Psychiatrie
May 29, 2008
Leopold Hermle, K.‐a. Kovar, Walter Hewer et al.
24 citations
OBJECTIVE: The purpose of this article is to provide an overview of the current research on hallucinogen induced psychiatric disorders. In addition to LSD and psilocybin hallucinogens of biologic origin are increasingly used by adolescents and young adults. METHODS: Relevant literature and related articles were identified by means of a computerized MEDLINE search including the years 1997 -...
Anthropology of Consciousness
September 1, 2007
Andy Letcher
30 citations
This paper addresses the question of what happens to consciousness under the influence of psychedelic drugs—specifically of psilocybin, or “magic” mushrooms— and performs a Foucauldian discourse analysis upon the answers that have been variously proposed. Predominant societally legitimated answers (the pathological, psychological, and prohibition discourses) are those that, in Foucault's sense,...