Frontiers in Psychology
January 23, 2020
Elizaveta Solomonova, Simon Dubé, Cloé Blanchette-Carrière et al.
9 citations
Aim: Rapid eye movement (REM) sleep, non-rapid eye movement (NREM) sleep, and sleep spindles are all implicated in the consolidation of procedural memories. Relative contributions of sleep stages and sleep spindles were previously shown to depend on individual differences in task processing. However, no studies to our knowledge have focused on individual differences in experience with Vipassana...
Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
January 2020
Rachael Sumner, Rebecca McMillan, Meg J. Spriggs et al.
The rapid-acting clinical effects of ketamine as a novel treatment for depression along with its complex pharmacology have made it a growing research area. One of the key mechanistic hypotheses for how ketamine works to alleviate depression is by enhancing long-term potentiation (LTP)-mediated neural plasticity. The objective of this study was to investigate the plasticity hypothesis in 30...
Neuroscience & Biobehavioral Reviews
January 2020
Rafael Guimarães Dos Santos, Jaime Eduardo Cecilio Hallak
Serotoninergic hallucinogens include drugs such as lysergic acid diethylamide (LSD), dimethyltryptamine (DMT) and psilocybin. Recent trials with single/few doses of these compounds show that they induce rapid and sustained antidepressive, anxiolytic, and antiaddictive effects. These effects are also observed in religious groups using the DMT-containing brew ayahuasca. The agonist action of...
Therapeutic Advances in Psychopharmacology
2020
D. Matveychuk, Rejish K Thomas, Jennifer Swainson et al.
209 citations
Ketamine, a drug introduced in the 1960s as an anesthetic agent and still used for that purpose, has garnered marked interest over the past two decades as an emerging treatment for major depressive disorder. With increasing evidence of its efficacy in treatment-resistant depression and its potential anti-suicidal action, a great deal of investigation has been conducted on elucidating ketamine’s...
Libro Comunicaciones
2020
R. Pinilla, Psicologa Clara Rodriguez, Diana Batet et al.
Objetivo: Exponer los potenciales beneficios terapéuticos del uso de ayahuasca, desde la neurofarmacología y la evidencia clínica existente hasta el momento. Material y métodos: Se realizó una revisión de la literatura en las bases de datos pubmed, clinical key y textos de difusión científica. Resultados y conclusiones: Existe literatura acerca del potencial uso terapéutico del ayahuasca en...
Pharmacology, Biochemistry, and Behavior
December 9, 2019
Satoshi Deyama, Ronald S. Duman
181 citations
Clinical and preclinical studies have demonstrated that depression, one of the most common psychiatric illnesses, is associated with reduced levels of neurotrophic factors, including brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGF), contributing to neuronal atrophy in the prefrontal cortex (PFC) and hippocampus, and reduced hippocampal adult neurogenesis....
European Journal of Neuroscience
December 6, 2019
Ronald S. Duman, Satoshi Deyama, Manoela V. Fogaça
319 citations
The pathophysiology and treatment of depression have been the focus of intense research and while there is much that remains unknown, modern neurobiological approaches are making progress. This work demonstrates that stress and depression are associated with atrophy of neurons and reduced synaptic connectivity in brain regions such as the hippocampus and prefrontal cortex that contribute to...
Behavioral Neuroscience
December 1, 2019
Clemens C C Bauer, Camila Caballero, Ethan Scherer et al.
The impact of mindfulness training on stress and associated brain plasticity has been shown in adults, whereas the impact of such training in the developing brain remains unknown. To address this open question, 40 middle-school children were randomized to either mindfulness or coding training (active control) interventions during the school day for eight weeks. Outcome measures were ratings of...
bioRxiv (Cold Spring Harbor Laboratory)
November 21, 2019
Roberto Guidotti, Cosimo Del Gratta, Mauro Gianni Perrucci et al.
1 citation
preprint
Abstract The effects of intensive meditation practices on the functional and structural organization of the human brain have been addressed by a growing number of neuroscientific studies. However, the different modulations of meditation expertise and of ageing, in the underlying brain areas and networks, have not yet been fully elucidated. These effects should be distinguished in order to...
Behavioural Brain Research
November 6, 2019
Mei-Dan Wei, Yuhong Wang, Kun Lu et al.
Post-traumatic stress disorder (PTSD) is a chronic and disabling condition arising after exposure to a severe traumatic event, which affects approximately eight percent of the population. The underlying neurobiology of PTSD, however, has only been partially understood. The exploration of fear memory and its extinction has been the subject to increase our understanding of PTSD. Our previous...