Ketamine as an antidepressant: overview of its mechanisms of action and potential predictive biomarkers
Therapeutic Advances in Psychopharmacology 2020 D. Matveychuk, Rejish K Thomas, Jennifer Swainson et al. 209 citations
Ketamine, a drug introduced in the 1960s as an anesthetic agent and still used for that purpose, has garnered marked interest over the past two decades as an emerging treatment for major depressive disorder. With increasing evidence of its efficacy in treatment-resistant depression and its potential anti-suicidal action, a great deal of investigation has been conducted on elucidating ketamine’s...