European Psychiatry
2024
Eline Haijen, Petra P M Hurks, Kim P. C. Kuypers
10 citations
Abstract Adults with attention-deficit hyperactivity disorder (ADHD) often struggle with emotion regulation (ER), impacting their empathic skills and relationships. ADHD medication might not be as effective for ER issues as for ADHD symptoms. Microdosing (MD) psychedelics has shown promise for ADHD treatment and previous studies reported social-emotional benefits. Two online prospective studies...
JCEM Case Reports
December 15, 2023
Ebne Rafi, Claudia Lewis, Betul Hatipoglu
Abstract Total pancreatectomy and autologous islet transplantation (TPAIT) is a procedure to ameliorate dysglycemia associated with post-pancreatectomy. Patients who undergo TPAIT are at risk of developing hypoglycemia postoperatively. The current literature suggests that hypoglycemia may be due to a glucagon-deficiency state. To date, there is minimal literature available that explores...
npj Mental Health Research
November 8, 2023
Omer A. Syed, Benjamin Tsang
4 citations
The recent years have seen an unprecedented surge of psychedelic research. Studies with psilocybin (colloquially known as magic mushrooms), in particular, have shown promise in ameliorating symptoms of treatment-refractory depression, anxiety, and substance use disorder, among others 1 , 2 . Microdosing, the practice of regularly taking roughly a tenth of full psychedelic doses, is becoming...
PsyArXiv
November 7, 2023
Mika Turkia
2 citations
preprint
Following advice received in a dream, a woman in her early thirties, suffering from depression, anxiety, and sleep disorders caused by complex trauma in her childhood, experimented with 'microdosing' or psycholytic dosing of Amanita muscaria (fly agaric) mushrooms. During a 3.5-month period with an intuition-based, gradually declining dosing scheme, her symptoms significantly decreased. No...
bioRxiv Preprint Server
November 7, 2023
Kelly E. Dunham, Kani H. Khaled, Leah Weizman et al.
preprint
Recently, the FDA approved microdosing ketamine for treatment resistant depression. Traditional antidepressants, like serotonin selective reuptake inhibitors (SSRIs), block serotonin reuptake, but it is not clear if ketamine blocks serotonin reuptake. Here, we tested the effects of feeding ketamine and SSRIs to Drosophila melanogaster larvae, which has a similar serotonin system to mammals, and...
Frontiers in Psychiatry
October 16, 2023
Eline Haijen, Petra P M Hurks, Kim P. C. Kuypers
6 citations
Background Microdosing (MD), repeatedly taking psychedelics in small, non-hallucinogenic amounts, has been practiced by individuals to relieve attention deficit hyperactivity disorder (ADHD) symptoms. Generally, adults diagnosed with ADHD have lower levels of mindfulness and differ in personality structure from non-ADHD adults. How MD affects mindfulness and personality in adults with ADHD...
Pilot and Feasibility Studies
October 5, 2023
Carina Joy Donegan, Dimitri Daldegan-Bueno, Rachael Sumner et al.
23 citations
Globally, an estimated 260 million people suffer from depression [1], and there is a clear need for the development of new, alternative antidepressant therapies. In light of problems with the tolerability and efficacy of available treatments [2], a global trend is emerging for patients to self-treat depression with microdoses of psychedelic drugs such as lysergic acid diethylamide (LSD) and...
Journal of Psychedelic Studies
September 11, 2023
Ioana Pop, Erwin Gielens, Hannah Kottmann
1 citation
Abstract Background and aims Microdosing psychedelics refers to the practice of repeatedly ingesting doses that do not reach the threshold for perceptual alterations. This practice has gained attention from mass media, businesses, and the general public, as evidenced by the proliferation of online communities dedicated to it. In this contribution, we examine the content generated within the...
Journal of Psychopharmacology
August 12, 2023
Michael Tagen, Daniel Mantuani, Alex Holstein et al.
39 citations
Psychedelic microdosing is the practice of taking very low doses of psychedelic substances, typically over a longer period of time. The long-term safety of chronic microdosing is relatively uncharacterized, but valvular heart disease (VHD) has been proposed as a potential risk due to activation of the serotonin 5-HT 2B receptor. However, this risk has not yet been comprehensively assessed. This...
Cannabis and Cannabinoid Research
August 9, 2023
Abhinandan Banerjee, William Hosie, Ana Carolina Terso Ventura et al.
Background: This article highlights the formulation of a solid Δ9-tetrahydrocannabinol (THC)-loaded ingestible prepared from pure THC distillate. Methods: A THC-containing ethanol-assisted cannabinoid nanoemulsion (EACNE) was created using a solvent displacement technique. Subsequently, the EACNE was converted to a solid powdery material while still retaining its THC potency, a format uniquely...