Sensors
January 20, 2023
Víctor Cuadrado-Peñafiel, Adrián Castaño-Zambudio, Luis Manuel Martínez-Aranda et al.
Introduction: The implementation of optimal sprint training volume is a relevant component of team sport performance. This study aimed to compare the efficiency and effectiveness of two different configurations of within-season training load distribution on sprint performance over 6 weeks. Methods: Twenty male professional FH players participated in the study. Players were conveniently assigned...
Journal of Psychedelic Studies
January 17, 2023
Ioana Pop, Jannis Dinkelacker
4 citations
Abstract Background and aims Previous research has proposed that microdosing, i.e., the repeated use of sub-threshold doses of serotonergic hallucinogens, has an impact on mood by increasing emotional awareness. We propose that increased emotional awareness could translate into higher emodiversity, a balanced experience of emotions in which emotions are experienced with more similarity in...
Substance Use & Misuse
2023
Barbara Andraka-Christou, Matthew Douglas Evans, Beth Tranen et al.
Background: Opioid overdose deaths in the U.S. continue to increase, largely due to the prevalence of fentanyl, a very powerful opioid, in the illicit drug supply. Buprenorphine treatment is effective for treating opioid use disorder, but it can be challenging for clinicians to introduce buprenorphine treatment to people who use fentanyl due to risks of precipitated withdrawal. Induction could...
Base
2023
André Adjogboto, Dagnon Didier Likpètè, C. Sossa-Vihotogbe et al.
Description of the subject. Fertilizers microdosing was tested for African leafy vegetables (ALVs) production to reduce the high rates of fertilizers usually applied to their production in West Africa. Objectives. This study aims to (i) evaluate the response of three ALVs (Amaranthus cruentus L., Solanum macrocarpon L. and Ocimum gratissimum L.) to cattle manure combined with urea-N microdosing...
Journal of Labelled Compounds and Radiopharmaceuticals
2023
Yong Gong, Rhys Salter
Ibrutinib is an oral medication for the treatment of B cell malignancies. During its clinical development, a stable isotopologue of ibrutinib was required for the assessment of the drug's absolute oral bioavailability via intravenous microdosing. The following work describes a 10‐step, gram‐scale production of carbon‐13 labeled ibrutinib from [13C6]phenol (13C6, 99%) in 31% overall yield with...
KWI-Blog
2023
Stefan Höhne
2 citations
2023-07-24
International Journal of Environmental Research and Public Health
December 8, 2022
Amer Raheemullah, Ori-Michael Benhamou, Jamie Kuo et al.
Buprenorphine is a partial opioid agonist that is Food and Drug Administration (FDA) approved to treat chronic pain and opioid use disorder (OUD). The national prescribing guidelines in the United States (US) recommend that patients transitioning from full opioid agonists to buprenorphine first undergo 12 or more hours of active opioid withdrawal, in order to avoid buprenorphine-precipitated...
Psychopharmacology
December 1, 2022
Ido Hartogsohn, Rotem Petranker
22 citations
The use of psychedelics for medical and recreational purposes is rising. Contextual factors such as expectancy, intention, and sensory and social environment (set and setting) are widely recognized as moderating the effects of these substances. Nevertheless, clinical trials of microdosing - the ingestion of small, sub-hallucinogenic doses of psychedelics - rarely report their set and setting....
Neuroscience Applied
October 26, 2022
Eline Haijen, Petra P M Hurks, Kim P. C. Kuypers
17 citations
ADHD in adulthood is often overlooked, which negatively affects the individual's well-being. First-line pharmacological interventions are effective in many ADHD patients, relieving symptoms rapidly. However, there seems to be a proportion of individuals who discontinue, or fail to respond to these treatments. For these individuals, alternative treatment options should be explored. A...
October 19, 2022
Stefan Baumann, Robin Carhart-Harris, David Nutt et al.
2 citations
preprint
Microdosing is the practice of regularly using very low doses of psychedelic drugs. Anecdotal reports suggest that it may enhance well-being, creativity and cognition. Here, we use data from a self-blinding microdose trial, a large (n=240) placebo-controlled citizen science trial of microdosing to investigate whether tolerance develops during microdosing. We conceptualized tolerance as the...