Cytochrome P450 (CYP) enzymes play a central role in the elimination of approximately 80% of all clinically used drugs. Differences in CYP enzyme activity between individuals can contribute to interindividual variability in exposure and, therefore, treatment outcome. In vivo CYP enzyme activity could be determined with phenotyping. Currently, (sub)therapeutic doses are used for in vivo...
Background: Buprenorphine initiation in opioid-tolerant patients usually requires decreasing the total opioid intake per day due to its potential for precipitating withdrawal. However, this strategy may not be tolerated in patients who require higher amounts of opioids, such as those with cancer pain. Case Presentation: We utilized a buprenorphine microdosing strategy for a postoperative cancer...
Microdosing psychedelic drugs at a level below the threshold to induce hallucinations is an increasingly common lifestyle practice. However, the effects of microdosing on sleep have not been previously reported. Here, we report results from a Phase 1 randomized controlled trial in which 80 healthy adult male volunteers received a 6-week course of either LSD (10 µg) or placebo with doses...
Background and aim: In the present study, we focus on the relationship between state authenticity - the experience of being true to oneself in a particular moment - and microdosing - a practice that implies repeatedly ingesting very small doses of psychedelics that do not reach the threshold for perceptual alterations. We propose that microdosing could increase state authenticity through...
Abstract Microdosing psychedelics has garnered considerable attention within both nonprofessional circles and the scientific community in recent years. This method involves taking small, non-hallucinogenic doses of substances like LSD or psilocybin over weeks or months, purportedly to enhance specific behaviors, emotions, or address psychiatric conditions. Exploring these assertions is crucial...
The practice of microdosing classic psychedelic drugs (e.g. LSD [lysergic acid diethylamide] and psilocybin) has not only become more commonplace, but has also been shown to have potential in treating various psychological impairments. Much is still unknown about how people who microdose psychedelic drugs learn the processes and protocols for microdosing. To uncover how people learn the various...
Abstract Introduction Maize production in smallholder farmers located in semiarid areas of Zimbabwe are mainly constrained by soil moisture and nutrient stress. Moisture stress is mainly due to erratic rainfall, high rates of evapotranspiration and limited knowledge of the use of in situ rainwater harvesting (IRWH) techniques. Tied ridges (TRs) are one of the best IRWH techniques which have...
Capillary dried blood spot (DBS) analysis coupled with multi-analyte steroid liquid chromatography mass spectrometry (LCMS) is attractive for field studies, home-based self-sampling as well as clinical trials by eliminating costly and laborious sample processing involving venipuncture and frozen storage/shipping while providing multiple steroid measurements from a single small sample. We...
In the present contribution, we examine the practice of microdosing psychedelics (microdosing) through textual analysis of the content produced by a dedicated online community, the r/microdosing subreddit. We collected a comprehensive dataset of publicly available submissions from this community and used structural topic modelling to identify and analyse the prevalent topics within the...
Smallholder maize farmers are currently confronted with the arduous challenge of managing limited financial resources while incessantly facing the issue of land degradation. To address this issue, an alternative solution has been implemented to optimize the use of chemical fertilizer by adopting microdosing. This innovative system not only helps them enhance their agricultural productivity but...