Abstract Background The practice of psychedelic microdosing has grown outside of the medical realm from a community of self-medicating users who endorse improvements in cognitive functioning and mental health. The breadth and strength of this advocacy has led many to replace traditional psychotropic medication and well-being support with an under researched practice. This represents a divide...
Microdosing psychedelics, the regular use of low doses of LSD or psilocybin, have attracted growing public and scientific interest. This review synthesizes findings from 57 human studies on psychological and physiological outcomes in clinical and non-clinical populations. Reported benefits include improved mood, enhanced cognition, social functioning, and mental health, although findings are...
Abstract Background Depressive disorders affect about 280 million people worldwide, with many struggling to find effective relief. Conventional antidepressants are widely prescribed but often lack efficacy and have side effects, leaving many patients dissatisfied or untreated. Concurrently, psychedelic therapies have gained momentum in both research and ‘in the wild’, with emerging evidence...
Background: Premenstrual dysphoric disorder (PMDD) is a severe mood disorder characterised by depression, irritability, mood lability, anxiety and physical symptoms that occur exclusively in the last week/s of the menstrual cycle. With a growing global interest in microdosing of psychedelic drugs, an increase in self-medication has occurred, including by those with PMDD. Aim: Qualitative...
An important safety consideration for topically administered drugs is the extent of systemic exposure they achieve. The aim of this study was to evaluate whether a topically administered microdose of the model drug diclofenac can predict the systemic availability, plasma, and tissue pharmacokinetics of a topical therapeutic dose. Eight healthy participants (6 men and 2 women) participated in a...
Microdosing of lysergic acid diethylamide (LSD) over a 6‐week period showed no significant benefits over placebo in reducing symptoms of attention‐deficit hyperactivity disorder (ADHD) in adults, a Phase 2A trial has found. Both the LSD and placebo groups experienced marked improvement, the investigators reported.
CureusJuly 1, 2025Akshita Suleria, Sakshi Verma, Khanij Arya et al.
Lysergic acid diethylamide (LSD) is an ergot-derived psychedelic agent that produces perceptual and psychic effects of heightened sensations by acting on the dopaminergic, adrenergic, and serotonergic pathways in the brain and periphery, with 5-hydroxytryptamine 2A (5-HT2A) as the primary target molecule. Its action on these receptors in the central nervous system is comparatively well studied...
This pilot study explored the potential of microdosing 1-cyclopropionyl-d-lysergic acid diethylamide (1cp-LSD) to treat canine anxiety. A single-case study was conducted on a 13-year-old female dog with severe separation anxiety, who was treated with 5 µg of 1cp-LSD every 3 days for a month. Anxiety was assessed before, after, and 1 month following treatment using a validated questionnaire. The...
The aim of this study was to develop a novel workflow to identify human urine biomarkers for drugs of abuse and new psychoactive substances. Metabolites of amphetamine, cocaine, LSD, MDMA, methamphetamine, THC, MDMB-CHMICA, and MDPPP were first identified in a zebrafish embryo (ZE) metabolism study followed by comparison to most abundant human metabolites in literature. Finally, metabolites...
Optimizing organic fertilizer recommendations can be cost-effective and affordable for resource-poor farmers by increasing crop yield and income. This field experiment was conducted to determine the most effective vermicompost application method for enhancing maize production in the Laelay Adiyabo district (Chiraro, Gudelo, and Hibret experimental sites) of Tigray, Ethiopia, during the 2019...
The purpose of this narrative review is to examine the hypothesis that two neuropeptides, vasopressin (VP) and oxytocin (OT) and their receptors have central roles in the behavioral and physiological consequences of psychedelic interventions. Transient consequences of psychedelics can include anxiety and in some cases sickness responses such as nausea and vomiting, which may involve VP and...
BJPsych OpenJune 1, 2025Zelda Summers, Jennie Rankine, Stuart Fisher
Aims: For patients prescribed methadone wishing to access buprenorphine ORT, the current practice is to reduce the methadone dose to 30/40 ml and cessation of methadone for 48 hrs prior to the switch. This exposes these patients to risk of psychological, physical distress or relapse into non-prescribed opiate use. Using guidance published by the Canadian Journal of Addiction we adapted this to...
Do-it-yourself (DIY) brain hacking has evolved from fringe experimentation to a cultural and clinical phenomenon reshaping how individuals interact with their brains. From early self-directed use of racetam nootropics, at-home transcranial direct current stimulation, and meditation apps, to the normalization of microdosing psychedelics, this movement reflects a broader shift toward brain...
Her earrings tremble as she tilts her head.Voice cracking, he mimes the difficulty of spooning soup up to his mouth.The MRI's pixels reflect off his glasses, obscuring the worry in his eyes.
Microdosing, the repeated use of psychedelic substances at low doses, is growing in popularity among recreational consumers. While this practice is associated with many benefits to mood, well-being and health, research in this area is in its early stages and predominantly centered on human applications. In this narrative review, we synthesize the findings from studies investigating the effects...
CureusMay 1, 2025Alyssa Kong, Viseth Long, Elle Wang et al.
Introduction To address the rising deaths and hospitalizations related to opioid toxicity, buprenorphine/naloxone has been provided as a frontline treatment within the emergency department (ED), allowing increased access to opioid agonist therapies (OAT). However, several barriers exist toward initiating patients on buprenorphine/naloxone within the ED, such as shortages in healthcare staff and...
Microdosing is the practice of taking psychedelic drugs at doses that produce no or minimal perceptible subjective or behavioural effects. This study investigated the pharmacokinetics and pharmacodynamics of microdosed lysergic acid diethylamide (LSD). This was a Phase 1 double-blind placebo-controlled parallel-groups trial with 80 healthy male volunteers (four withdrawals due to anxiety)....
Abstract This study aimed to determine the optimal maize NPK microdosing rate in Mali and compare labor requirements for mechanized versus manual sowing and fertilization across three locations with varying rainfall. The treatments included six microdosing rates, ranging from zero to 93 kg NPK/ha (3 g NPK/hill), and the recommended rate of 100 kg NPK/ha applied by row application. All...
This review is limited by the heterogeneity in reporting side effects and the short duration of many studies. Future studies should transparently and systematically present a description of side effects.
Existing research highlights an increase in psychedelic microdosing, particularly for therapeutic purposes and as a means for self-enhancement. However, we know little about the different routes into and out of microdosing, particularly by those who do not consume other illicit substances, and of the processes involved in the development, maintenance, and cessation of practices. Drawing upon a...