Side effects of microdosing lysergic acid diethylamide and psilocybin: A systematic review of potential physiological and psychiatric outcomes
Stefan Modzelewski, Anna Stankiewicz, Napoleon Waszkiewicz, Kacper Łukasiewicz
Neuropharmacology March 7, 2025 DOI: 10.1016/j.neuropharm.2025.110402 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review Peer reviewed |
|---|---|
| Topics | LSD Microdosing Psilocybin |
| Keywords | Adverse reactions Side effects Psychedelics hallucinogens Microdosing sub-perceptual dosing Entheogens |
| Citations | 5 |
| Key findings | Heterogeneity in reporting side effects and short study durations limit current psychedelic research, and future studies should transparently and systematically present side effect descriptions. |
Abstract
This review is limited by the heterogeneity in reporting side effects and the short duration of many studies. Future studies should transparently and systematically present a description of side effects.
Comparable studies
Other narrative reviews on LSD and microdosing, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| The risk of chronic psychedelic and MDMA microdosing for valvular heart disease | 2023 | Review | |
| Macrodosing to microdosing with psychedelics: Clinical, social, and cultural perspectives | 2022 | Review | |
| Is microdosing a placebo? A rapid review of low-dose LSD and psilocybin research | 2024 | Rapid review | n = 19 |
| Microdosing Psychedelics to Restore Synaptic Density in Schizophrenia. | 2025 | Review | |
| Self-medication with psychedelics: a scoping review and narrative synthesis of review-level evidence Self-medicating individuals | 2026 | Scoping review |
Citations in the library
Cited by 7
- DT120 (MM120): a single-dose orally disintegrating formulation of lysergide tartrate for generalized anxiety disorder Expert Review of Neurotherapeutics October 8, 2026
- Psilocybin, From Ancestral Use to Therapeutic Potential: A Multidimensional Review of Its Pharmacological Basis and Current Perspectives Human Psychopharmacology: Clinical and Experimental September 1, 2026
- Psychedelic Safety and Clinical Outcomes Across Exposure Patterns: A Structured Narrative Review Life August 14, 2026
- Psilocybin and Mental Health Outcomes: Scoping Review with ☸SAIMSARA SAIMSARA Journal June 15, 2026
- Therapeutic Divergence in 5-HT2A Agonism: Psilocybin and Phenalkylamines for Demoralization Syndrome ACS Medicinal Chemistry Letters August 15, 2025
and 2 more in the library
Cites 63
- Psilocybin produces substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer: A randomized double-blind trial Journal of Psychopharmacology November 30, 2016
- Human hallucinogen research: guidelines for safety. Journal of Psychopharmacology July 1, 2008
- Measurement of dissociative states with the Clinician‐Administered Dissociative States Scale (CADSS) Journal of Traumatic Stress 1998
- Safety, Tolerability, and Efficacy of Psilocybin in 9 Patients With Obsessive-Compulsive Disorder The Journal of Clinical Psychiatry November 15, 2006
- Safety and Efficacy of Lysergic Acid Diethylamide-Assisted Psychotherapy for Anxiety Associated With Life-threatening Diseases The Journal of Nervous and Mental Disease March 4, 2014
and 58 more in the library