Exercise microdosing has been adopted in sports to maintain physical capacities throughout the competitive season. This study aimed to determine whether in-season Nordic hamstring exercise (NHE) microdosing could retain eccentric hamstring strength after a preseason NHE program. Thirty-four athletes completed a 5-week preseason program including a typical-volume NHE protocol (up to 60...
GLP-1 drugs have changed the face of weight loss. But amid high prices and obstacles to access, people are attempting experimental small doses. Are the drugs effective at these doses—and is microdosing GLP-1s safe?
This hypothesis and perspective article proposes that dosing schedule should be treated as an independent pharmacological variable in psilocybin microdosing research. Existing controlled studies relevant to depression and mood have predominantly used intermittent schedules. The first dedicated randomized trial in major depressive disorder used 2 mg psilocybin once weekly and did not demonstrate...
The biological component of soil health, particularly bacteria and fungi, plays a central role in organic matter decomposition, nutrient cycling and mineralization, thereby contributing to the maintenance of soil fertility and overall soil functioning. However, continuous cultivation, inadequate nutrient replenishment and inappropriate fertilizer management can lead to soil degradation. Soil...
This commentary summarizes the pharmacologic rationale, emerging evidence, clinical considerations, and limitations of microdosing glucagon-like peptide-1 (GLP-1)-based therapies. Microdosing of single or dual GLP-1 receptor agonists (RAs) has emerged as an off-label strategy to improve tolerability, reduce cost, and expand access during periods of medication shortages. Although standard doses...
Irrigation and DrainageSeptember 22, 2026Mouiz W. I. A. Yessoufou, Pierre G. Tovihoudji, Sissou Zakari et al.
ABSTRACT: Maize productivity depends on grain‐filling, which requires understanding the interactions among genotype, water and nutrient management. However, these interactions remain poorly investigated in Sub‐Saharan Africa (SSA). This study investigates the influence of supplemental irrigation (SI) and fertiliser microdosing on grain‐filling and yields of maize varieties. Field experiment...
This hypothesis and perspective article proposes that uninterrupted daily low-dose psilocybin may constitute a pharmacologically distinct receptor-adaptation paradigm. Repeated 5-HT2A agonist pulses could progressively produce functional desensitization, internalization, and/or down-regulation; the fading of acute subjective effects may therefore mark the development of an adaptive state rather...
Millet (Pennisetum glaucum (L.) R. Br.), the most widely grown cereal in Senegal, plays an important role in food security. However, its production remains limited by low soil fertility and by mineral fertilisation practices that are often ill-suited to the various agroecological zones and the varieties grown. This study assessed the effect of different microdose mineral fertilisation options...
Abstract Background Depressive disorders affect approximately 280 million people worldwide, with many patients finding existing treatments ineffective or limited by adverse effects. Growing evidence from community microdosing reports suggests that psychedelic therapies may help alleviate depressive symptoms. Among these, lysergic acid diethylamide (LSD) microdosing has shown particular promise...
The combined microdose of NPK and urea could be a sustainable intensification strategy for sesame cultivation in semi-arid areas of West Africa.This study evaluated the effects of different NPK microdose treatments, both alone and in combination with urea, on sesame productivity and economic profitability in the North Sudanese zone of Burkina Faso.The trial was conducted in 2019 and 2020 at the...
The biophysical field-based evaluation of the endogenous soil and water conservation (SWC) practices in the hilly region of sub-Saharan West Africa is lacking. To address this, the current study aims to evaluate the most commonly used erosion control practices in the hilly region of Boukombé through a rainfed field experiment conducted under sorghum over two growing seasons (2012–2013) on a...
IntroductionMicrodosing psilocybin magic mushrooms (MM) and truffles has grown in popularity, but the evidence supporting reported benefits remains poorly characterized. The purpose of this systematic review was to synthesize the existing literature on microdosing psilocybin MM and truffles in adults to determine reported health effects and perceived benefits, motivations for use, dosing...
Abstract Background Current gender-affirming hormone therapy (GAHT) guidelines are optimized for binary outcomes (full masculinization or feminization), leaving a critical evidence gap for the growing population of non-binary and gender-diverse (NBGD) individuals who seek partial physical changes. These non-traditional therapeutic goals often necessitate the off-label use of low-dose,...
Pearl millet ( Pennisetum glaucum (L.) R. Br) is a very important cereal crop in the semi-arid regions of West Africa, serving as a primary food source for local populations. Therefore, its productivity remains lowered by soil degradation and low availability of inputs as fertilizers. In this context, biofertilizers and organic amendments offer sustainable and ecological alternatives for...
CureusJuly 2026Mia A Panlilio, Natalie Piserchio, Mercedes Hennessey et al.
Glucagon-like peptide-1 (GLP-1) is an endocrine hormone that plays a role in lowering blood glucose levels and promoting weight loss. GLP-1 receptor agonists (GLP-1 RAs) are synthetic peptides that mimic the activity of GLP-1, and the recent development of GLP-1 RA medications has been a major historical advancement in the treatment of diabetes and obesity. Despite the rapid development of...
Psilocin (4-hydroxy-N, N-dimethyltryptamine) is a substituted tryptamine alkaloid and a nonselective serotonergic agonist acting predominantly at 5-HT2A/C receptors, with substantial binding to 5-HT1A and 5-HT2B receptors. Microdosing is the practice of taking a very small, sub-perceptual dose, typically 5% to 10% of a full recreational dose, to improve mood, creativity, and focus without...
Background: Psychedelic microdosing—repeated sub-perceptual doses of lysergic acid diethylamide (LSD) or psilocybin—has attracted scientific interest as a potential mood and cognitive intervention. The evidence base remains methodologically heterogeneous and vulnerable to expectancy bias. Methods: We conducted an umbrella review with narrative synthesis following Joanna Briggs Institute...
= 26.38, ~50% past-month cannabis use by design) completed an online survey. Multivariable regression assessed sociodemographics, mental health, and adverse childhood events (ACEs) in relation to: (1) past-year psychedelic use; and (2) among those reporting lifetime use: (a) lifetime microdosing and (b) use motives. Lifetime and past-year psychedelic use were 27.7% and 11.9% (commonly...
Microdosing and related low-dose psychoactive practices have become increasingly visible in discussions of mental health, cognition, creativity, emotional regulation, pain, sleep, spirituality, and psychological flexibility. However, the term microdosing is often used as if it referred to a single pharmacological phenomenon. More precisely, it describes a low-dose application pattern used...
This work aims to assess the S65487-induced disruption of the B-cell lymphoma-2 (Bcl2)/Bcl2-like protein 11 (Bim) complex at therapeutic doses via a pharmacokinetic/pharmacodynamic model and to reconcile pharmacokinetic data from microdoses and therapeutic doses in a single population pharmacokinetic model. The first model consists of a linear 3-compartment pharmacokinetic model linked to an...