An important safety consideration for topically administered drugs is the extent of systemic exposure they achieve. The aim of this study was to evaluate whether a topically administered microdose of the model drug diclofenac can predict the systemic availability, plasma, and tissue pharmacokinetics of a topical therapeutic dose. Eight healthy participants (6 men and 2 women) participated in a...
Positron emission tomography (PET)-microdosing comprises the administration of a carbon-11- or fluorine-18-labelled drug candidate to human subjects in order to describe the drug's concentration-time profile in body tissues targeted for treatment. As PET microdosing involves the administration of only microgram amounts of unlabelled drug, the potential toxicological risk to human subjects is...
Near-death experiences (NDEs) are purported by many researchers and experi encers to produce positive changes in life attitudes, such as a sense of purpose, acceptance of death, concern for others, and an awareness of the value of life. This study explores the association between NDEs and subsequent attitude changes through the responses of 28 near-death experiencers on the Life Attitude...