In this chapter, I examine the undocumented history of mescaline in medical and psychiatric circles in France by reconstructing the scientific context in which Jean-Paul Sartre's famous bad trip took place in February 1935. 1 In this way, we can first consider that the very term "bad trip," sometimes ascribed to the experience retrospectively 2 on the basis of accounts by Simone de Beauvoir...
Peyote (Lophophora williamsii) is an entheogenic and medicinal cactus native to the Chihuahuan desert. The psychoactive and hallucinogenic properties of peyote are principally attributed to the phenethylamine derivative mescaline. Despite the isolation of mescaline from peyote over 120 years ago, the biosynthetic pathway in the plant has remained undiscovered. Here, we use a transcriptomics and...
The small, globular cactus peyote (Lophophora williamsii) is known for its ability to produce mescaline, a phenethylamine protoalkaloid (Figure 1). Consuming the mescaline-containing dried tops or “buttons” of peyote has a psychedelic effect that has been used in religious ceremonies by Indigenous communities for over 5800 years (Cassels & Sáez-Briones, 2018). Nowadays, psychedelic drugs are...
Narrative criminology prioritizes personal narratives for explaining past behaviours and shaping future decisions. Using this perspective, we rely on data from a photo-ethnography with people who use peyote in religious ceremonies to understand how their discourses about peyote shape their experiences with it. We find that participants define peyote as an ‘earth medicine’ that helps with...
Mescaline, lysergic acid diethylamide (LSD), and psilocybin are classic serotonergic psychedelics. A valid, direct comparison of the effects of these substances is lacking. The main goal of the present study was to investigate potential pharmacological, physiological and phenomenological differences at psychoactive-equivalent doses of mescaline, LSD, and psilocybin. The present study used a...
Vitamin D3, omega-3s show no protection against late-life depression Some older adults with subthreshold depression or at high risk for depression might have elevated inflammation or poor vascular and metabolic health, suggesting that supplementation could improve mood in these individuals. An ancillary study to a trial of vitamin D3 and omega-3 fatty acids examined the effects of these...
Abstract This article follows the transsensory pathways opened by peyote, a mood-altering entheogen, as it diffused among Native peoples living under and along the edges of colonial occupation around the turn of the twentieth century. It traces that movement through the pulsions of temporal and sensorial animacy created in the episodic narration of The Autobiography of a Winnebago Indian...
Abstract Background and Aims Both Peyote and San Pedro cacti contain mescaline, a classical psychedelic eliciting mystical and visual effects, but only Peyote is a vulnerable species. We sought to address the questions 1; do people who use Peyote substitute with San Pedro, and vice versa, and; 2. how popular is the use of wild harvested mescaline cactus compared with the use of cultivated...
El san Pedro (Trichocereus spp.), un cactus rico en mezcalina, y la Anadenanthera colubrina (vilca en kichwa), son plantas enteógenas (cosas que nos llevan a lo divino) prominentes en el arte andino. Este artículo explora la flor que corona este cactus (de diez pulgadas de ancho) y las numerosas variantes de este motivo exhibidas en 64 textiles wari. Las representaciones artísticas de la flor...
Introduction Differentiating whether plant products are natural or artificial is of great importance in many practical fields, including forensic science, food safety, cosmetics, and fast-moving consumer goods. Information about the topographic distribution of compounds is an important criterion for answering this question. However, of equal importance is the likelihood that topographic spatial...