Page 127 of 346: studies 1,261 to 1,270 of 3,454, newest first. Back to the MDMA overview
British Journal of Pharmacology May 1, 2010
Methylenedioxymethamphetamine inhibits mitochondrial complex I activity in mice: a possible mechanism underlying neurotoxicity.
Toxicology April 11, 2010 Helena Pontes, Paula Guedes de Pinho, Eduarda Fernandes et al.
3,4-Methylenedioxymethamphetamine (MDMA; ecstasy), a drug of abuse commonly consumed at rave parties, is often taken in a polydrug abuse scenario, ethanol being one of the most associated drugs. Both MDMA and ethanol are mainly metabolized in the liver with formation of toxic metabolites. Our working hypothesis is that ethanol can modify the metabolism of MDMA through the cytochrome P450...
Emergency Medicine Journal April 8, 2010 Cédric M. Hysek, Franz X. Vollenweider, Matthias E. Liechti 50 citations
The results of this study indicate that beta-blockers may prevent increases in heart rate but not hypertensive and adverse effects of MDMA.
Current drug targets April 2010 Patricia Robledo
3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") is an amphetamine derivative with psychostimulant properties. This substance is widely used around the world by young adults in recreational settings. One of the most remarkable characteristic of ecstasy users is the concurrent consumption of several other drugs of abuse including psychostimulants, alcohol, tobacco, LSD, cannabis and opioids....
The FASEB Journal April 1, 2010 Kevin T. Ball
MDMA is a widely used amphetamine derivative that increases dopamine and serotonin transmission via its interaction with monoamine transporters. Compared to other psychostimulants, little is known about the long‐term neurobehavioral effects of MDMA. We conducted a series of studies aimed at elucidating the effects of MDMA administration on behavior, limbic cortico‐striatal neuronal structure,...
The International Journal of Neuropsychopharmacology March 25, 2010 Joyce Colussi‐mas, Richard J. Wise, Alex Howard et al. 51 citations
In laboratory animals, exposure to priming injections of 3,4-methylenedioxymethamphetamine (MDMA) produced drug seeking following extinction of MDMA self-administration. This study aimed to evaluate whether the magnitude of drug seeking was related to latency to acquisition of MDMA self-administration and increases in striatal dopamine, as measured by in-vivo microdialysis. Rats were given...
Behavioral and Brain Functions March 22, 2010 Carmen Manzanedo, Marta Rodríguez‐arias, Manuel Daza‐losada et al. 36 citations
Abstract Background Numerous reports indicate that MDMA users consume other psychoactive drugs, among which cannabis is one of the most common. The aim of the present study was to evaluate, using the conditioned place preference, the effect of the cannabinoid agonist WIN 55,212-2 on the rewarding effects of MDMA in mice. Methods In the first experiment adolescent mice were initially conditioned...
Neurochemistry International March 19, 2010
A long hangover from party drugs: residual proteomic changes in the hippocampus of rats 8 weeks after γ-hydroxybutyrate (GHB), 3,4-methylenedioxymethamphetamine (MDMA) or their combination.
Behavioural Brain Research March 5, 2010 Rómeó D. Andó, Csaba Ádori, Eszter Kirilly et al.
To assess the functional state of the serotonergic system, the acute behavioural and brain metabolic effect of SSRI antidepressants were studied during the recovery period after MDMA-induced neuronal damage. The effects of the SSRI fluoxetine and the serotonin receptor agonist meta-chloro-phenylpiperazine (m-CPP) were investigated in the social interaction test in Dark Agouti rats, 6 months...
British Journal of Pharmacology March 3, 2010 James R. Docherty, Ar Green 88 citations
Hyperthermia is probably the most widely known acute adverse event that can follow ingestion of 3,4‐methylenedioxymethamphetamine (MDMA, ecstasy) by recreational users. The effect of MDMA on body temperature is complex because the drug has actions on all three major monoamine neurotransmitters [5‐hydroxytryptamine (5‐HT), dopamine and noradrenaline], both by amine release and by direct receptor...