Drug seeking in response to a priming injection of MDMA in rats: relationship to initial sensitivity to self-administered MDMA and dorsal striatal dopamine
Joyce Colussi‐mas, Richard J. Wise, Alex Howard, Susan Schenk
The International Journal of Neuropsychopharmacology March 25, 2010 DOI: 10.1017/s1461145710000283 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Sample size | 20 |
| Population | Laboratory rats |
| Intervention | MDMA self-administration |
| Dose | 10.0 mg/kg i.p. |
| Topics | MDMA |
| Keywords | Dopamine Self-administration Microdialysis Pharmacology Striatum Drug Catecholamine Extinction optical mineralogy Anesthesia |
| Citations | 51 |
| Key findings | Drug seeking after extinction of MDMA self-administration was negatively correlated with latency to acquire self-administration and positively correlated with MDMA-induced dopamine release in the dorsal striatum. |
Abstract
In laboratory animals, exposure to priming injections of 3,4-methylenedioxymethamphetamine (MDMA) produced drug seeking following extinction of MDMA self-administration. This study aimed to evaluate whether the magnitude of drug seeking was related to latency to acquisition of MDMA self-administration and increases in striatal dopamine, as measured by in-vivo microdialysis. Rats were given daily access to MDMA self-administration until they earned a total of 240 infusions (total intake of 165 mg/kg MDMA). Twelve of the 20 rats acquired self-administration within the temporal limits of the study and the latency to meet the criterion ranged from 9 d to 37 d. An experimenter-administered injection of MDMA (10.0 mg/kg i.p.) produced drug seeking in these rats, and the number of responses was significantly higher than responses produced by rats that failed to meet the criterion or by yoked control rats that received the drug passively. For rats that met the criterion, drug seeking was negatively correlated with the number of days to self-administer the criterion number of MDMA infusions and positively correlated with MDMA-produced dopamine in the dorsal striatum. Importantly, MDMA-produced dopamine overflow was greater for the rats that met the criterion. These findings suggest that drug seeking is influenced by initial sensitivity to the reinforcing effects of MDMA and to drug-produced increases in striatal dopamine.
Comparable studies
Other preclinical and animal studies on MDMA, most cited first.
Citations in the library
Cited by 23
- Intravenous self-administration of mephedrone, methylone and MDMA in female rats Neuropharmacology January 17, 2015
- The preclinical pharmacology of mephedrone; not justMDMAby another name British Journal of Pharmacology March 24, 2014
- Dopaminergic mechanisms of reinstatement of MDMA‐seeking behaviour in rats British Journal of Pharmacology December 30, 2010
- Acquisition of MDMA self‐administration: pharmacokinetic factors and MDMA‐induced serotonin release Addiction Biology June 14, 2013
- Methylenedioxymethamphetamine (MDMA): Serotonergic and dopaminergic mechanisms related to its use and misuse Journal of Neurochemistry March 12, 2021
and 18 more in the library
Cites 14
- Neurotoxicity of the psychedelic amphetamine, methylenedioxymethamphetamine. Journal of Pharmacology and Experimental Therapeutics 1987
- MDMA self‐administration in rats: acquisition, progressive ratio responding and serotonin transporter binding European Journal of Neuroscience November 16, 2007
- Conditioning following repeated exposure to MDMA in rats: Role in the maintenance of MDMA self-administration. Behavioral Neuroscience 2006
- Effects of priming injections of MDMA and cocaine on reinstatement of MDMA- and cocaine-seeking in rats. Drug and Alcohol Dependence August 1, 2008
- Tolerance to 3,4-methylenedioxymethamphetamine in rats exposed to single high-dose binges. Neuroscience March 27, 2008
and 9 more in the library