Toxicological sciences : an official journal of the Society of Toxicology
March 2010
Déborah Hirt, Julien Fonsart, Marie-Claude Menet et al.
The pharmacokinetics of the recreational drug 3,4-methylenedioxymethamphetamine (MDMA) and its mains metabolites have never been modeled together. We therefore designed a model with which to analyze the pharmacokinetics of MDMA, 3,4-methylenedioxyamphetamine (MDA), 4-hydroxy-3-methoxymethamphetamine (HMMA), and 4-hydroxy-3-methoxyamphetamine (HMA) and to test the effect of covariates like...
Psychopharmacology
March 1, 2010
Effects of repeated MDMA administration on the motivation for palatable food and extinction of operant responding in mice.
Toxicology Letters
February 24, 2010
Identification of post-generation effect of 3,4-methylenedioxymethamphetamine on the mouse brain by large-scale gene expression analysis.
ACS Chemical Neuroscience
February 23, 2010
Reduced 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy)-initiated oxidative DNA damage and neurodegeneration in prostaglandin H synthase-1 knockout mice.
February 16, 2010
Margaret Stutley
Shamanism is one of the earliest and farthest-reaching magical and religious traditions, vestiges of which still underlie the major religious faiths of the modern world. The function of the shaman is to show his or her people the unseen powers behind the mere appearances of nature, as experienced through intuition, in trance states, or during ecstatic mystical visions. Shamans possess healing...
PLoS One
February 10, 2010
Clara Touriño, Andreas Zimmer, Olga Valverde
55 citations
The majority of MDMA (ecstasy) recreational users also consume cannabis. Despite the rewarding effects that both drugs have, they induce several opposite pharmacological responses. MDMA causes hyperthermia, oxidative stress and neuronal damage, especially at warm ambient temperature. However, THC, the main psychoactive compound of cannabis, produces hypothermic, anti-inflammatory and...
Cambridge University Press eBooks
February 4, 2010
Vibeke S. Catts, Stanley V. Catts
12 citations
Facts box Phencyclidine (PCP), ketamine, D-lysergic acid diethylamide (LSD) and 3, 4-methylenedioxy-methamphetamine (MDMA) have been variously referred to as schizophrenomimetics, psychotogens, or psychotomimetics. There have been many reports that these drugs can induce psychotic symptoms (hallucinations, delusions, formal thought disorder, or catatonia-like abnormalities) in the absence of...
Journal of Psychopharmacology
February 1, 2010
G. Bedi, NT Van Dam, J. Redman
Although previous studies have examined anxiety and depression in ecstasy (±3,4-methylenedioxymethamphetamine; MDMA) users, it remains unclear whether symptoms are associated specifically with ecstasy or with polydrug use in general. We compared mean symptomatology and clinically significant symptoms in 45 ecstasy polydrug, 48 cannabis polydrug and 40 legal drug users, who completed...
Journal of Psychopharmacology
February 2010
L Craig, John E. Fisk, C Montgomery et al.
Previous findings report use of the drug ecstasy (MDMA) to be associated with lower emotional intelligence (EI), and compromised functioning in brain areas responsible for emotion. This study explored the relationship between ecstasy use, EI, mood and parenting styles. Questionnaire measures of drug use, lifestyle, parenting style and EI were obtained, with separate IQ measures for fluid...
Drug and Alcohol Dependence
February 1, 2010
Louisa Degenhardt, R. Bruno, Libby Topp
This paper examines the evidence for an MDMA or "ecstasy" dependence syndrome. Animal evidence suggests that MDMA may be a less potent reinforcer than other drugs, but that it does have dependence potential. This suggests that (a) ecstasy dependence might be less likely than dependence upon other drugs; and (b) factors related to the behavioural and psychological aspects of reward and...