A long hangover from party drugs: residual proteomic changes in the hippocampus of rats 8 weeks after γ-hydroxybutyrate (GHB), 3,4-methylenedioxymethamphetamine (MDMA) or their combination.
Neurochemistry International March 19, 2010 DOI: 10.1016/j.neuint.2010.03.002 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Preclinical experimental study Peer reviewed |
|---|---|
| Population | Rats |
| Interventions | GHB MDMA |
| Duration | 8 weeks post-exposure |
| Topics | MDMA |
| Key findings | Eight weeks after a single binge-like exposure, GHB, MDMA, and their combination each produced residual changes in hippocampal protein expression compared to controls, indicating long-lasting molecular effects in the brain. |
Abstract
A long hangover from party drugs: residual proteomic changes in the hippocampus of rats 8 weeks after γ-hydroxybutyrate (GHB), 3,4-methylenedioxymethamphetamine (MDMA) or their combination.
Comparable studies
Other preclinical and animal studies on MDMA, most cited first.
Citations in the library
Cited by 6
- Acute and Long-Term Behavioural Effects of MDMA in Adolescent Rats The Open Addiction Journal March 29, 2011
- Adaptive Plasticity in the Hippocampus of Young Mice Intermittently Exposed to MDMA Could Be the Origin of Memory Deficits. Molecular Neurobiology December 2016
- Looking for prosocial genes: ITRAQ analysis of proteins involved in MDMA-induced sociability in mice. European Neuropsychopharmacology November 2014
- MDMA: interactions with other psychoactive drugs. Pharmacology, Biochemistry, and Behavior October 2011
- Increased oxidative-modifications of cytosolic proteins in 3,4-methylenedioxymethamphetamine (MDMA, ecstasy)-exposed rat liver. PROTEOMICS January 2011
and 1 more in the library
Cites 11
- (+/–)3,4-Methylenedioxymethamphetamine (MDMA) Dose-Dependently Impairs Spatial Learning in the Morris Water Maze after Exposure of Rats to Different Five-Day Intervals from Birth to Postnatal Day Twenty Developmental Neuroscience 2009
- Extensive neuroadaptive changes in cortical gene-transcript expressions of the glutamate system in response to repeated intermittent MDMA administration in adolescent rats BMC Neuroscience April 17, 2008
- Pharmacological aspects of the combined use of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) and gamma-hydroxybutyric acid (GHB): a review of the literature Drug and Alcohol Review July 1, 2005
- Analysis of Ecstasy (MDMA)‐induced transcriptional responses in the rat cortex The FASEB Journal December 1, 2002
- Residual social, memory and oxytocin-related changes in rats following repeated exposure to γ-hydroxybutyrate (GHB), 3,4-methylenedioxymethamphetamine (MDMA) or their combination. Psychopharmacology August 21, 2010
and 6 more in the library