Archives of Toxicology
November 2018
Ana Margarida Araújo, Maria de Lourdes Bastos, Eduarda Fernandes et al.
3,4-Methylenedioxymethamphetamine (MDMA, ecstasy) is a well-known hepatotoxic drug. Although its toxicity has been thoroughly studied at high concentrations, there is still insufficient knowledge on possible alterations of cell function at subtoxic concentrations, which are in fact more representative concentrations of intoxication scenarios. In this study, a gas chromatography-mass...
Archives of Toxicology
August 1, 2015
Ana Margarida Araújo, Félix Carvalho, Maria de Lourdes Bastos et al.
290 citations
In the area of psychotropic drugs, tryptamines are known to be a broad class of classical or serotonergic hallucinogens. These drugs are capable of producing profound changes in sensory perception, mood and thought in humans and act primarily as agonists of the 5-HT2A receptor. Well-known tryptamines such as psilocybin contained in Aztec sacred mushrooms and N,N-dimethyltryptamine (DMT),...
Forensic Science International
September 1, 2014
Fernando Xavier Moreira, Félix Carvalho, Maria de Lourdes Bastos et al.
13 citations
Lately, the hallucinogenic plant Salvia divinorum has been considered a popular recreational product among adolescents, being legally sold in several countries in "smartshops" and in internet websites. Sellers frequently omit the safety information about the plant, encouraging its use for recreational purposes, without providing adequate qualitative and quantitative details. The principal...
Toxicology
April 11, 2010
Helena Pontes, Paula Guedes de Pinho, Eduarda Fernandes et al.
3,4-Methylenedioxymethamphetamine (MDMA; ecstasy), a drug of abuse commonly consumed at rave parties, is often taken in a polydrug abuse scenario, ethanol being one of the most associated drugs. Both MDMA and ethanol are mainly metabolized in the liver with formation of toxic metabolites. Our working hypothesis is that ethanol can modify the metabolism of MDMA through the cytochrome P450...