British Journal of Pharmacology
May 24, 2010
Natacha Vanattou‐saïfoudine, Ruth Mcnamara, Andrew Harkin
39 citations
Background and purpose: Caffeine exacerbates the hyperthermia associated with an acute exposure to 3,4 methylenedioxymethamphetamine (MDMA, ‘Ecstasy’) in rats. The present study investigated the mechanisms mediating this interaction. Experimental approach: Adult male Sprague‐Dawley rats were treated with caffeine (10 mg·kg −1 ; i.p.) and MDMA (15 mg·kg −1 ; i.p.) alone and in combination. Core...
Human & Experimental Toxicology
May 20, 2010
Pinchas Halpern, Jenny Moskovich, Beni Avrahami et al.
54 citations
Methods: We conducted a prospective, representative-sample nationwide study on morbidity related to 3,4, methylenedioxymethamphetamine (MDMA; ‘ecstasy’) as determined from admissions to 5 geographically representative emergency departments (EDs) and from data from the poison information center (PIC). MDMArelated ED admissions were analyzed over a 7-month period and the records of all PIC calls...
Journal of Pharmacological Sciences
May 19, 2010
Sustained exposure to 3,4-methylenedioxymethamphetamine induces the augmentation of exocytotic serotonin release in rat organotypic raphe slice cultures.
Brain
May 17, 2010
Stephen J. Kish, Jason P. Lerch, Yoshiaki Furukawa et al.
170 citations
Animal data indicate that the recreational drug ecstasy (3,4-methylenedioxymethamphetamine) can damage brain serotonin neurons. However, human neuroimaging measurements of serotonin transporter binding, a serotonin neuron marker, remain contradictory, especially regarding brain areas affected; and the possibility that structural brain differences might account for serotonin transporter binding...
Journal of Neuroscience Research
May 15, 2010
Eva L Van Donkelaar, Paul A. Kelly, Neil Dawson et al.
The serotonergic (5-hydroxytryptamine; 5-HT) dysfunction found in depression may affect not only brain function (mood) but also cerebrovascular control. Similar, but possibly occult, disturbances may also be induced by 3,4-methylenedioxymethamphetamine-induced neurotoxicity (MDMA, or "ecstasy"). Acute tryptophan depletion (ATD) is widely used to identify vulnerability to depression, and we...
Journal of Pharmacology and Experimental Therapeutics
May 13, 2010
Endocrine and neurochemical effects of 3,4-methylenedioxymethamphetamine and its stereoisomers in rhesus monkeys.
Addiction Biology
May 11, 2010
Tolerance to 3,4-methylenedioxymethamphetamine is associated with impaired serotonin release.
Psychopharmacology
May 2, 2010
Caffeine promotes dopamine D1 receptor-mediated body temperature, heart rate and behavioural responses to MDMA ('ecstasy').
Psychopharmacology
May 2010
Jessica McClung, William E Fantegrossi, Leonard L. Howell
The effectiveness of MDMA and its enantiomers to reinstate responding previously maintained by drug self-administration has not been thoroughly investigated. The present study was designed to compare the reinstatement effects of amphetamine, the piperazine-analog BZP, SR(+/-)-MDMA, S(+)-MDMA, R(-)-MDMA, and fenfluramine on behavior maintained under a second-order schedule of intravenous...
Accident; Analysis and Prevention
May 1, 2010
Risky car following in abstinent users of MDMA.