Neurochemistry International - The Consciousness Library

Esketamine attenuates post-traumatic stress disorder via suppressing neuroinflammation and abnormal myelination.

Neurochemistry International November 19, 2025 Zhaoliang Gu, Ruixue Song, Guoqiang Liu et al. 3 citations

Post-traumatic stress disorder (PTSD) is a chronic psychological disorder that is induced by traumatic events. The pathophysiological mechanism of PTSD involves complex neurobiological processes. However, the underlying mechanism is not clear, leading to lack of effective therapeutic interventions. Mice were exposed to the electric foot shocks using the contextual fear memory paradigm. A...

DOI: 10.1016/j.neuint.2025.106089 Full text Fear memory Myelination Neuroinflammation Esketamine For PTSD +1

Acute ketamine enhances social behavior and dendritic plasticity in the amygdala by increasing BDNF, GAP43, and TRKB presence following excitotoxic neonatal ibotenic acid lesion.

Neurochemistry International July 1, 2025 Nestor I Martínez-Torres, Jhonathan Cárdenas-Bedoya, Blanca Miriam Torres-Mendoza

Schizophrenia is a highly disabling psychopathology that is a significant burden on public health systems and is characterized by both positive and negative symptoms. One of these negative symptoms is social isolation, which responds poorly to available treatments. Ketamine (KET) has been shown to enhance social behavior in various preclinical models, accompanied by neurobiological changes. In...

DOI: 10.1016/j.neuint.2025.106016 Full text Brain plasticity Bdnf Gap43 Trkb +10

Subthreshold doses of guanosine plus ketamine elicit antidepressant-like effect in a mouse model of depression induced by corticosterone: Role of GR/NF-κB/IDO-1 signaling.

Neurochemistry International July 8, 2020 A. Camargo, A. P. Dalmagro, Julia M. Rosa et al.

Augmentative treatment is considered the best second-option when a first-choice drug has partial limitations, particularly by allowing antidepressant dose reduction. Considering that ketamine has significant knock-on effects, this study investigated the effects of single coadministration with subthreshold doses of ketamine plus guanosine in a corticosterone (CORT)-induced animal model of...

DOI: 10.1016/j.neuint.2020.104797

Linking phencyclidine intoxication to the tryptophan-kynurenine pathway: Therapeutic implications for schizophrenia.

Neurochemistry International May 1, 2019 Hidetsugu Fujigaki, Akihiro Mouri, Yasuko Yamamoto et al.

Phencyclidine (PCP) is a dissociative anesthetic that induces psychotic symptoms and neurocognitive deficits in rodents similar to those observed in schizophrenia patients. PCP administration in healthy human subjects induces schizophrenia-like symptoms such as positive and negative symptoms, and a range of cognitive deficits. It has been reported that PCP, ketamine, and related drugs such as...

DOI: 10.1016/j.neuint.2019.02.001 Full text Kynurenic acid Kynurenine pathway Phencyclidine Quinolinic acid +1

Methoxetamine: A foe or friend?

Neurochemistry International 2019 Chrislean Jun Botanas, June Bryan De la Peña, Hee Jin Kim et al.

Methoxetamine (MXE) is an N-methyl-D-aspartate (NMDA) receptor antagonist that is chemically and pharmacologically similar to other dissociative substances, such as ketamine and phencyclidine. There are reports on the misuse of MXE, which sometimes resulted in adverse consequences and death. Studies have also shown that MXE has abuse liability and stimulates dopamine neurotransmission in the...

DOI: 10.1016/j.neuint.2018.10.020 Full text Abuse liability Antidepressant Intoxication Methoxetamine

Catharanthine alkaloids are noncompetitive antagonists of muscle-type nicotinic acetylcholine receptors.

Neurochemistry International September 1, 2010 Hugo R Arias, Dominik Feuerbach, Katarzyna M Targowska-Duda et al. 9 citations

We compared the interaction of several catharanthine alkaloids including, ibogaine, vincristine, and vinblastine, with that for the noncompetitive antagonist phencyclidine (PCP) at muscle nicotinic acetylcholine receptors (AChRs) in different conformational states. The results established that catharanthine alkaloids: (a) inhibit, in a noncompetitive manner, (+/-)-epibatidine-induced Ca(2+)...

DOI: 10.1016/j.neuint.2010.05.007 Full text Neuropharmacology Receptor inhibition

Phencyclidine animal models of schizophrenia: approaches from abnormality of glutamatergic neurotransmission and neurodevelopment.

Neurochemistry International 2007 Akihiro Mouri, Yukihiro Noda, Takeshi Enomoto et al.

In humans, phencyclidine (PCP), a non-competitive N-methyl-d-aspartate (NMDA) receptor antagonist, reproduces a schizophrenia-like psychosis including positive symptoms, negative symptoms and cognitive dysfunction. Thus, the glutamatergic neuronal dysfunction hypothesis is one of the main explanatory hypotheses and PCP-treated animals have been utilized as an animal model of schizophrenia. The...

DOI: 10.1016/j.neuint.2007.06.019 Full text

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