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MDMA: all studies

Page 124 of 345: studies 1,231 to 1,240 of 3,446, newest first. Back to the MDMA overview

Research

Cocaine, metamfetamine, and MDMA abuse: the role and clinical importance of neuroadaptation.

Clinical Toxicology August 2010 Donna Seger

This article reviews the role and clinical importance of specific neuroadaptations that may occur following use of cocaine, metamfetamine, and 3,4,methylenedioxymetamfetamine (MDMA). A literature search was performed using OVID MEDLINE and PubMed for all years to the present date, which identified 250 papers of which 154 were considered relevant. MECHANISMS OF ACTION OF COCAINE AND...

DOI: 10.3109/15563650.2010.516263 (opens in new tab) Full text (opens in new tab)

Rediscovering MDMA (ecstasy): the role of the American chemist Alexander T. Shulgin

Addiction August 1, 2010 Udo Benzenhöfer, Torsten Passie 69 citations

ABSTRACTAims Alexander T. Shulgin is widely thought of as the ‘father’ of +/−3,4‐methylenedioxymethamphetamine (MDMA). This paper re‐assesses his role in the modern history of this drug.Methods We analysed systematically Shulgin's original publications on MDMA, his publications on the history of MDMA and his laboratory notebook.Results According to Shulgin's book PIHKAL (1991), he synthesized...

DOI: 10.1111/j.1360-0443.2010.02948.x (opens in new tab) MDMA History Alexander shulgin MDMA Therapy

The safety and efficacy of {+/-}3,4-methylenedioxymethamphetamine-assisted psychotherapy in subjects with chronic, treatment-resistant posttraumatic stress disorder: the first randomized controlled pilot study.

Journal of Psychopharmacology July 19, 2010 Michael C Mithoefer, Mark T Wagner, Ann T Mithoefer et al. 672 citations

Case reports indicate that psychiatrists administered ±3,4-methylenedioxymethamphetamine (MDMA) as a catalyst to psychotherapy before recreational use of MDMA as 'Ecstasy' resulted in its criminalization in 1985. Over two decades later, this study is the first completed clinical trial evaluating MDMA as a therapeutic adjunct. Twenty patients with chronic posttraumatic stress disorder,...

DOI: 10.1177/0269881110378371 (opens in new tab) Full text (opens in new tab) Psychedelic therapy Trauma therapy PTSD Management Mental health treatment +13

Chronic Stress Enhances the Corticosterone Response and Neurotoxicity to +3,4-Methylenedioxymethamphetamine (MDMA): The Role of Ambient Temperature

Journal of Pharmacology and Experimental Therapeutics July 16, 2010 Bethann N. Johnson, Bryan K. Yamamoto 22 citations

Stress facilitates drug abuse by humans. In rodents, stress enhances the neurochemical, neuroendocrine, and behavioral responses to psychostimulants. Although chronic unpredictable stress (CUS) enhances the acute hyperthermic and long-term monoamine-depleting effects of the psychostimulant +3,4-methylenedioxymethamphetamine (MDMA), the roles of hyperthermia and corticosterone (CORT) in...

DOI: 10.1124/jpet.110.171322 (opens in new tab) Full text (opens in new tab) MDMA Serotonin Monoamine neurotransmitter Corticosterone +8