Journal of Pharmacological Sciences - The Consciousness Library

Chronic corticosterone biases conflict-related behavior and abolishes ketamine's anticonflict effect in mice.

Journal of Pharmacological Sciences August 1, 2026 Natsuko Hitora-Imamura, Yuki Nishida, Koki Kawazoe et al.

Animals must balance reward seeking against potential danger, and impairments in such conflict decision-making are common in psychiatric disorders. Here, we examined how chronic corticosterone exposure and ketamine affect conflict behavior in mice by presenting them with a three-compartment conflict task. Three weeks of corticosterone increased conflict levels without inducing anhedonia,...

DOI: 10.1016/j.jphs.2026.05.004 Full text Ketamine Conflict behavior Corticosterone

Enhanced effect of the hallucinogen DOI in L-DOPA receptor Gpr143-deficient mice.

Journal of Pharmacological Sciences June 1, 2026 Daiki Masukawa, Rei Tajika, Yoshimi Ichimaru et al.

Hallucinogens, such as lysergic acid diethylamide, act primarily through the 5-hydroxytryptamine 2A (5-HT2A) receptor, but their regulatory mechanisms remain unclear. G protein-coupled receptor 143 (GPR143), an L-3,4-dihydroxyphenylalanine (L-DOPA) receptor, modulates specific GPCRs. We examined the role of GPR143 in the action of 5-HT2A receptor agonist 2,5-dimethoxy-4-iodoamphetamine (DOI)....

DOI: 10.1016/j.jphs.2026.04.002 Full text 5-ht2a receptor 2,5-dimethoxy-4-iodoamphetamine Gpr143

Involvement of N-methyl-D-aspartate receptor GluN2C/GluN2D subunits in social behavior impairments in mice exposed to social defeat stress as juveniles.

Journal of Pharmacological Sciences March 1, 2025 Mikio Yoshida, Hikari Katada, Yuya Isozumi et al. 4 citations

Glutamatergic system dysfunction is associated with the pathophysiology of stress-related psychiatric disorders. However, the role of N-methyl-D-aspartate (NMDA) receptor GluN2C and GluN2D subunits in the pathophysiology of adverse juvenile experiences remain unclear. This study aimed to investigate the involvement of GluN2C and GluN2D subunits in social behavior impairments in mice exposed to...

DOI: 10.1016/j.jphs.2024.12.007 Full text Ketamine Glun2c/glun2d-containing nmda receptor Social behavior impairment Mental health +6

Loss of the sustained antidepressant-like effect of (2R,6R)-hydroxynorketamine in NMDA receptor GluN2D subunit knockout mice.

Journal of Pharmacological Sciences March 1, 2024 Aimi Yamagishi, Yuiko Ikekubo, Masayoshi Mishina et al. 6 citations

Ketamine, an N-methyl-d-aspartate (NMDA) receptor antagonist, has attracted attention for its acute and sustained antidepressant effects in patients with depression. Hydroxynorketamine (HNK), a metabolite of ketamine, exerts antidepressant effects without exerting ketamine's side effects and has attracted much attention in recent years. However, the detailed pharmacological mechanism of action...

DOI: 10.1016/j.jphs.2024.01.008 Full text Glun2d Hydroxynorketamine Tail-suspension test Depression treatment +3

Derivatives of methoxetamine and major methoxetamine metabolites potently block NMDA receptors.

Journal of Pharmacological Sciences December 1, 2022 Tomohiko Irie, Yuta Yanase, Yosuke Demizu et al. 2 citations

N-Methyl-D-aspartate receptors (NMDARs) in the brain are influenced by psychoactive drugs such as 2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one (ketamine) and its analog 2-(ethylamino)-2-(3-methoxyphenyl)-cyclohexanone (methoxetamine). The recreational methoxetamine use can cause several toxicities and methoxetamine-related deaths have also been reported. Therefore, it has been banned in...

DOI: 10.1016/j.jphs.2022.09.005 Full text N-methyl-d-aspartate receptors Deoxymethoxetamine Methoxetamine metabolites Methoxisopropamine

Discriminative Stimulus Effects of Hallucinogenic Drugs: a Possible Relation to Reinforcing and Aversive Effects

Journal of Pharmacological Sciences June 12, 2019 Tomohisa Mori, Kazumi Yoshizawa, Masahiro Shibasaki et al. 13 citations

The subjective effects of drugs are related to the kinds of feelings they produce, such as euphoria or dysphoria. One of the methods that can be used to study these effects is the drug discrimination procedure. Many researchers are trying to elucidate the mechanisms that underlie the discriminative stimulus effects of abused drugs (e.g., alcohol, psychostimulants, and opioids). Over the past...

DOI: 10.1254/jphs.12r08cp Full text

Neuropsychotoxicity of abused drugs: molecular and neural mechanisms of neuropsychotoxicity induced by methamphetamine, 3,4-methylenedioxymethamphetamine (ecstasy), and 5-methoxy-N,N-diisopropyltryptamine (foxy).

Journal of Pharmacological Sciences 2008 Takayuki Nakagawa, Shuji Kaneko 44 citations

Psychostimulants including amphetamines and cocaine, opioids including morphine, and some recreational drugs share the ability to cause drug dependence and addiction. Although these drugs of abuse primarily act on distinct molecular targets, such as monoamine transporters or receptors, they finally converge to common neural pathways. Several lines of evidence suggest that their chronic...

DOI: 10.1254/jphs.fm0070141 Full text

New Perspectives in the Studies on Endocannabinoid and Cannabis: Cannabinoid Receptors and Schizophrenia

Journal of Pharmacological Sciences 2004 Hiroshi Ujike, Yukitaka Morita 94 citations

Cannabis consumption may induce psychotic states in normal individuals, worsen psychotic symptoms of schizophrenic patients, and may facilitate precipitation of schizophrenia in vulnerable individuals. Recent studies provide additional biological and genetic evidence for the cannabinoid hypothesis of schizophrenia. Examinations using [3H]CP-55940 or [3H]SR141716A revealed that the density of...

DOI: 10.1254/jphs.fmj04003x4

Papers