A. David Smith

2 papers in the library · 194 citations · publishing 1971-1988

Papers

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Human platelet 5-hydroxytryptamine receptors: Binding of [3H]-lysergic acid diethylamide (LSD). Effects of chronic neuroleptic and antidepressant drug administration

Cellular and Molecular Life Sciences February 1, 1988 A. David Smith, David P. Geaney, Michael Schächter et al. 15 citations

Chronic treatment with phenothiazines and thioxanthenes has been found to enhance 5-HT-induced aggregation of human platelets. A method has been developed to study 5-HT2 receptor binding sites on platelets utilising [3H]-LSD and more recently 125I/LSD. Results are presented which suggest that the LSD binding site is indeed the 5-HT2 binding site and that the LSD binding characterises the...

DOI: 10.1007/bf01952198 Lysergic acid diethylamide Serotonin Phenothiazine Platelet +6

Inhibitory effect of chlorpromazine on the syndrome of hyperactivity produced by l‐tryptophan or 5‐methoxy‐N,N‐dimethyltryptamine in rats treated with a monoamine oxidase inhibitor

British Journal of Pharmacology December 1, 1971 A. David Smith 179 citations

1. The hyperactivity and hyperpyrexia produced by L-tryptophan in rats treated with a monoamine oxidase inhibitor was inhibited by chlorpromazine.2. Chlorpromazine did not inhibit the increased rate of synthesis of brain 5-hydroxytryptamine (5-HT) produced by tryptophan loading.3. Hyperactivity and hyperpyrexia were also produced by 5-methoxy-N,N-dimethyltryptamine (5-MeODMT) in rats....

DOI: 10.1111/j.1476-5381.1971.tb07222.x Serotonin Chlorpromazine Monoamine oxidase inhibitor Monoamine neurotransmitter +8