Neuroscience Research
September 1, 2026
Mersedeh Shamsedin
ABSTRACT Background Fronto-hippocampal desynchronization is linked to cognitive decline in Alzheimer's-like pathology, but whether psilocybin can restore this dysfunction is unknown. Methods Male rats received intracerebroventricular streptozotocin (ICV-STZ) to induce neurotoxicity, followed by a single dose of psilocybin (2.5 mg/kg, the maximum tolerated dose). Spatial memory, recognition...
Neuroscience Research
July 1, 2025
Kaixi Li, Nan Li, Yuanyuan Chen et al.
1 citation
Alpha-methyltryptamine (AMT), 5-methoxy-alpha-methyltryptamine (5-MeO-AMT), and 5-methoxy-N,N-diisopropyltryptamine (5-MeO-DiPT) are three synthetic tryptamines with hallucinogenic properties that are widely abused worldwide. The hallucinogenic effects of tryptamines are primarily related to activation of the 5-HT receptor, and among the many subtypes of 5-HT receptors, the 5-HT2A receptor is...
Neuroscience Research
December 7, 2024
Atsushi Yamaguchi, Tatsuya Jitsuishi
The precuneus is an association area in the posteromedial cortex (PMC) that is involved in high-order cognitive functions through integrating multi-modal information. Previous studies have shown that the precuneus is functionally heterogeneous and subdivided into several subfields organized by the anterior-posterior and ventral-dorsal axes. Further, the precuneus forms the structural core of...
Neuroscience Research
April 1, 2024
Aurelio Cortese, Mitsuo Kawato
Theories of consciousness abound. However, it is difficult to arbitrate reliably among competing theories because they target different levels of neural and cognitive processing or anatomical loci, and only some were developed with computational models in mind. In particular, theories of consciousness need to fully address the three levels of understanding of the brain proposed by David Marr:...
Neuroscience Research
April 2024
Xiyao Yu, Reona Yamaguchi, Tadashi Isa
The nature of subjective conscious experience, which accompanies us throughout our waking lives, and how it is generated, remain elusive. One of the challenges in studying subjective experience is disentangling the brain activity related to the sensory stimulus processing and stimulus-guided behavior from those associated with subjective perception. Blindsight, a phenomenon characterized by the...
Neuroscience Research
May 1, 2023
Keiichi Onoda, Hiroyuki Akama
Finding the neural basis of consciousness is challenging, and the distribution location of the core of consciousness remains inconclusive. Integrated information theory (IIT) argues that the posterior part of the brain is the hot zone of consciousness, especially phenological consciousness. The IIT has proposed a "main complex", a set of elements determined such that the information loss in a...
Neuroscience Research
June 13, 2011
Impact of meditation on emotional processing--a visual ERP study.
Neuroscience Research
April 2011
Takahiko Koike, Shigeyuki Kan, Masaya Misaki et al.
Recent studies have compared default-mode network (DMN) connectivity in different arousal levels to investigate the relationship between consciousness and DMN. The comparison between the DMN in rapid eye movement (REM) sleep with that in non-REM (NREM) sleep is useful for revealing the relationship between arousal level and DMN, because the arousal level is at its lowest during deep NREM, while...
Neuroscience Research
June 1, 2001
S Vukosavic, S Ruzdijic, R Veskov et al.
The purpose of the present study was to test changes in the expression of growth-associated protein (GAP-43) after chronic treatment with two different psychotomimetic drugs: amphetamine and phencyclidine. Rats were treated chronically for 7 days (twice daily) with 5 mg/kg of amphetamine and phencyclidine and sacrificed after 2, 5 or 7 days of treatment, and following 7, 14 or 21 days of...
Neuroscience Research
February 1986
J B Wei, C Y Chiang
Serotonergic and non-serotonergic neurons in the nucleus raphe magnus were identified by conduction velocities and spontaneous discharge rates. Eight of 13 serotonergic neurons were depressed by lysergic acid diethylamide (LSD) administration (40-50 micrograms/kg, i.p. or i.v.), while the others were non-responsive. Among 38 non-serotonergic neurons, 5 were depressed, 4 were excited and 29 were...